چکیده مقاله
This study is devoted to the optimization of mixing related parameters of a 400 L bioreactor applied for diphtheria bacteria culture the upstream process in the vaccine production process using the computational fluid dynamics CFD simulation method The effects of engineering parameters such as the type, agitation rate, and location of impeller on the hydrodynamic environment inside the bioreactor were studied Using a concaved blade disc CBDT impeller with an agitation rate of 550 rpm which is located in 30 cm distance from the bioreactor bottom, a superior improvement in air holdup 5 2% , bubbles size 4 31 mm and kLa value 0 30 s 1 was observed, as compared to the currently utilized bioreactor equipped with Rashton RT impeller located in 20 cm distance These results make the CFD assisted optimized 400 L bioreactor a potential candidate for this bioprocess
کلیدواژهها
نویسندگان
Parvaneh Esmaeilnejad-Ahranjani
Department of Anaerobic Bacterial Vaccine Research and Production, Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization AREEO , Karaj, Iran
Monireh Hajimoradi
Department of Immunology, Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization AREEO , Karaj, Iran
Masoumeh Bagheri
Department of Viral Vaccine Production, Razi Vaccine and Serum Research Institute, Agricultural Research,Education and Extension Organization AREEO , Karaj, Iran
شیوه ارجاع
Esmaeilnejad-Ahranjani, Parvaneh and Hajimoradi, Monireh and Bagheri, Masoumeh,1400,CDF simulation and investigation of the effect of mixing on air distribution in a stirred tank bioreactor,Fourth International Conference on Technology Development in Chemical Engineering,Tehran
ارائهشده در
مجموعه مقالات چهارمین کنفرانس بین المللی توسعه فناوری در مهندسی شیمی31 شهریور 1400 · تهران