چکیده مقاله
When it comes to cells separation from culture media and harvesting a purified product, centrifugation can be a potential technique Thus, this study is devoted to optimize the operational conditions of an industrial centrifuge to efficiently separate diphtheria bacterial cells from the culture medium using computational fluid dynamics CFD simulation method Multiphase Eulerian Eulerian model coupled with Gidaspow drag and standard k ε mixture turbulence models is used to quantify the complex hydrodynamics of the centrifuge and thus evaluate the efficiency of cells separation and possible cells damages under the centrifugal forces Consequently, the rotational speed of 1500 rpm and feed flow rate of 50 L h 1 are recommended as the optimized operational conditions for such a centrifuge
کلیدواژهها
نویسندگان
Parvaneh Esmaeilnejad-Ahranjani
Department of Anaerobic Bacterial Vaccine Research and Production, Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization AREEO , Karaj, Iran
Azadeh Zahmatkesh
Department of Anaerobic Bacterial Vaccine Research and Production, Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization AREEO , P O Box: ۳۱۹۷۵/۱۴۸,Karaj, Iran
Masoumeh Bagheri
Department of Viral Vaccine Production, Razi Vaccine and Serum Research Institute, Agricultural Research,Education and Extension Organization AREEO , P O Box: ۳۱۹۷۵/۱۴۸, Karaj, Iran
شیوه ارجاع
Esmaeilnejad-Ahranjani, Parvaneh and Zahmatkesh, Azadeh and Bagheri, Masoumeh,1400,CFD Simulation and optimization of an industrial tubular centrifuge for separation of diphtheria bacterial cells,Fourth International Conference on Technology Development in Chemical Engineering,Tehran
ارائهشده در
مجموعه مقالات چهارمین کنفرانس بین المللی توسعه فناوری در مهندسی شیمی31 شهریور 1400 · تهران