چکیده مقاله
Patients diagnosed with monoclonal gammopathy of undetermined significance MGUS are atan increased risk of developing hematological malignancies, mainly Multiple Myeloma MM ,and non hematological malignancies, including breast, prostate, and thyroid cancer The presentstudy aimed to investigate the underlying elemental genes responsible for MGUS progressioninto MM or breast cancer using a network based modeling approach through gene expressiondata followed by protein protein interaction PPI networks Three original gene expressionprofiles were downloaded, namely GSE42568, GSE29431, and GSE13591, from the GEOdataset, and the DEGs were obtained using R software The intersection of datasets foridentifying DEGs in MGUS with those calculated for MM and breast cancer has been obtainedusing the Venn Diagram PPI networks were constructed using the STRING database andvisualized with Cytoscape Hub genes for each overlap were obtained by PPI and sorted usingthe CytoHubba plugin by the degree of connection Final results, including genes like GAPDH, ATF3, ITGAM, FN1, COL1A1, ACADM, and the CD19 and CD17 gene expression relationship in MGUS and MM progression, not only harmonize smoothly with the current literature but also contribute to future advancements in cancer treatments
نویسندگان
Ali Salavati
Chemical and Petroleum Engineering Department, Sharif University of Technology, ۱۱۳۶۵‐۹۴۶۵, Tehran, Iran
شیوه ارجاع
Salavati, Ali,1402,Breaking the Chain of Progression: An Integrated Network-Based Perspectivefor Underlying MGUS Progression into Hematological and Non-Hematological Cancers,the seventh International Conference on Technology Development in Chemical Engineering,Tehran
ارائهشده در
مجموعه مقالات هفتمین کنفرانس بین المللی توسعه فناوری در مهندسی شیمی30 بهمن 1402 · تهران