چکیده مقاله
Targeted drug delivery is a promising approach to overcome the limitations of classical chemotherapy In this respect, Imatinib loaded PEG modified magnetic nanoparticles were prepared as a pH sensitive system for targeted delivery of drug to tumor sites by applying a magnetic field The proposed magnetic nanoparticles were prepared through modification of magnetic Fe3O4 nanoparticles with PEG400 and then Imatinib The structural, morphological and physicochemical properties of the synthesized nanoparticles were determined by different analytical techniques including energy dispersive X ray spectroscopy EDS , field emission scanning electron microscopy FE SEM , Fourier transform infrared FTIR spectroscopy, transmission electron microscopy TEM , vibrating sample magnetometry VSM , and X ray diffraction XRD UV/visible spectrophotometry was used to measure the Imatinib contents Drug loading and release profile of the prepared particles was investigated The results demonstrated that Fe3O4@PEG acts as a pH responsive nanocarrier in releasing the loaded Imatinib molecules Furthermore, the Fe3O4@PEG/Imatinib nanoparticles displayed cytotoxic effect against MCF 7 breast cancer cells
کلیدواژهها
نویسندگان
Marjan Shahriari
Maryam Shahriari
Maryam Shahriari
Marjan Shahriari
شیوه ارجاع
Shahriari, Marjan and Shahriari, Maryam,1399,Imatinib-loaded PEG-modified magnetic nanoparticles as an anti-cancer agent for pH responsive targeted drug delivery,International Conference on New Findings in Midwifery, Women, Childbirth and Infertility
ارائهشده در
مجموعه مقالات کنفرانس بین المللی یافته های نو در مامایی، زنان، زایمان و نازایی17 تیر 1399