چکیده مقاله
Background: Sleep disorders and amnesia have been known for many years as one of the most important health problems Sleep disturbance refers to cases in which a person complains of one or more of the problems such as amnesia, frequent awakenings during the night sleep, increased drowsiness during the day or abnormal movements, moods and feelings during sleep Sleep deprivation impairs the perception of pain, forgetfulness, and depression Approximately 30 to 40% of ordinary people suffer from it, this problem can have adverse effects on people's health and longevity Purpose: This study was performed to evaluate the effect of Resveratrol on amnesia caused by complete sleep deprivation in male laboratory rats at Tehran Islamic Azad University of Medical Sciences during 2019 20 Methods: In this animal study, 96 male rats weighing 220 to 240 g, purchased from the Faculty of Pharmacology, University of Tehran, were randomly divided into 3 main groups, including 7 day control group, 7 day sham and sleep deprivation It was 7 days SD with Non REM 48h Each of the main groups included 4 subgroups of control, vehicle, and drug 100 and 200 mg / kg The controls were normal mice receiving no medication Vehicle received only 0 25% carboxymethylcellulose solution Sigma Aldrich with 0 9% saline or rapamycin intraperitoneally daily for 7 days The drug was given only Resveratrol daily for 7 days at doses of 100 and 200 mg / kg intraperitoneally Each animal was tested only once The day after the last injection ie the eighth day , train behavioral tests fear condition and shock 3 times , locomotive, hot plate, and forced swimming test were performed on all rats, then all rats were given 48 hours of non REM sleep deprivation and Again, these behavioral tests were taken from rats Results: To evaluate conditioned fear memory, the rate of delay until the first freezing in the auditory stage was increased in mice that received the body P
کلیدواژهها
نویسندگان
Hesam Adin Atashi
Young Researchers and Elite Club, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
Mohammad Nasehi
Young Researchers and Elite Club, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
Zahra Nadia Sharifi
Young Researchers and Elite Club, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
Mohammad-Reza Zarrindast
Young Researchers and Elite Club, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
شیوه ارجاع
Adin Atashi, Hesam and Nasehi, Mohammad and Nadia Sharifi, Zahra and Zarrindast, Mohammad-Reza,1400,Effect of Resveratrol on amnesia caused by complete sleep deprivation in male laboratory rats,Fourth International Conference on New Findings in Midwifery, Obstetrics, Gynecology and Infertility
ارائهشده در
مجموعه مقالات چهارمین کنفرانس بین المللی یافته های نو در مامایی، زنان، زایمان و نازایی9 مرداد 1400