چکیده مقاله
Jaundice is one of the most common neonatal complications Therefore, promptly diagnosing and treating it is vital This study aimed to determine the effect of Fenofibrate and phototherapy compared to the phototherapy alone on total serum bilirubin TSB at 24 and 48 h primary outcome and side effects secondary outcome Methods: English Cochrane Library, Web of Science, Medline, CINAHL, PsycINFO, PubMed, and Google Scholar and Persian SID and Magiran databases were searched using verified keywords MeSH library without time constraint The risk of bias was assessed using the Cochrane Handbook RevMan software version 5 3 was used for meta analysis and the mean difference was calculated as effect size In heterogeneous cases, the random effect was reported instead of the fixed one Results: The total number of studies found in all databases was 5482 Six articles were included in the present study The results of the meta analysis showed no statistically significant difference in TSB levels within 24 Mean difference: 5 56; 95% Confidence Interval 95% CI : 4 53 to 16 05; P = 0 27 and 48 h 4 77; 2 57 to 12 10; P= 0 20 between Fenofibrate with phototherapy group and the phototherapy alone group No side effects have been reported in included studies Conclusion: Although the results of the five studies showed the significant effect of Fenofibrate as adjuvant therapy on reducing TSB level, the meta analysis failed to show the same result in the study groups It is recommended to perform more trials following all principles of randomized controlled trials to find an effective treatment for hyperbilirubinemia
کلیدواژهها
نویسندگان
Nasrin Zamiri-Miandoab
Students Research Committee, School of Nursing and Midwifery Tabriz University of Medical Sciences Tabriz, Iran
Reyhaneh Montazeri
Students Research Committee, School of Nursing and Midwifery Tabriz University of Medical Sciences Tabriz, Iran
Mojgan Mirghafourvand
Women's Reproductive Health Research Center Tabriz University of Medical Sciences Tabriz, Iran
Shirin Hassanzade
Social Determinants of Health Research Center Tabriz University of Medical Sciences Tabriz, Iran
شیوه ارجاع
Zamiri-Miandoab, Nasrin and Montazeri, Reyhaneh and Mirghafourvand, Mojgan and Hassanzade, Shirin,1400,Effect of Fenofibrate on Neonatal Hyperbilirubinemia: A Systematic Review and Meta-analysis,Fifth International Conference on New Findings in Midwifery, Obstetrics, Gynecology and Infertility
ارائهشده در
مجموعه مقالات پنجمین کنفرانس بین المللی یافته های نو در مامایی، زنان، زایمان و نازایی20 آبان 1400