چکیده مقاله
Introduction: Repeated implantation failure RIF is a major concern in reproductive medicine, despite several methods that have been described for management Dysfunction of embryo maternal immuno tolerance pathways can be one of the reasons of RIF It has been suggested that uterine natural killer cells are involved in establishment and maintenance of pregnancy and fetus through producing a range of cytokines To reach this goal, we used endometrium Immuno modulation prior to frozen embryo transfer for patients with repeated implantation failures Material and methods: peripheral blood mononuclear cells PBMC were isolated from RIF patients, cultured for 3 days and transferred into their uterus about two days before embryo transfer ET This method was performed on 68 patients and compared with 83 patients as control group Results: pregnancy rate was significantly increased in experimental group versus the control group 58 8% vs 41 2%, P= 0 04 Implantation rate in PBMC group was higher than the control group, but this increase was not statistically significant Perhaps this could be achieved by increasing cases Conclusion: Our study demonstrates that intrauterine insemination of PBMC increases pregnancy rates and can be used in RIF patients
کلیدواژهها
نویسندگان
P Mousavi Mehr
BSc, Novin fertility center, Mashhad, Iran Ferdowsi University of Mashhad, Mashhad, Iran
M Fadavi Islam
Ms, Novin fertility center, Mashhad, Iran
H Roustaei
MD, Novin fertility center, Mashhad, Iran
M Mansuri Torshizi
MD, Novin fertility center, Mashhad, Iran
Z Bazri
MD, Novin fertility center, Mashhad, Iran
R Mahdavian Zadeh
Ms, Novin fertility center, Mashhad, Iran
شیوه ارجاع
Mousavi Mehr, P and Fadavi Islam, M and Roustaei, H and Mansuri Torshizi, M and Bazri, Z and Mahdavian Zadeh, R,1400,Effects of autologous peripheral blood mononuclear cells on implantation and pregnancy rate in patients with repeated implantation failure,Fifth International Conference on New Findings in Midwifery, Obstetrics, Gynecology and Infertility
ارائهشده در
مجموعه مقالات پنجمین کنفرانس بین المللی یافته های نو در مامایی، زنان، زایمان و نازایی20 آبان 1400