چکیده مقاله
Objective: Women with polycystic ovary syndrome PCOS suffer from sympathetic nervous system SNS hyperactivity Clonidine as the alpha 2 adrenoceptor agonist is widely used for modulation of SNS output Study designThis study was designed in two sections: in vivo / in vitro and was performed from February 2016 to December 2017 Eighty women with PCO participated in this randomized clinical trial in vivo Polycystic ovary morphology PCOM and pregnancy rate were the main outputs which were evaluated by oral dosing of clonidine 0 1 mg tablet twice a day for two months A case/control study of cumulus cell culture was another part in vitro of this study Clonidine was added to the culture for two study groups PCO women with drug / without drug and two control groups egg donors with drug / without drug , that all of them were candidate for IVF Ovulation stimulant drugs were administrated for all groups After the puncture, cumulus cells were collected for treatment by clonidine ResultsThe pregnancy rate significantly more occurred in the clonidine group P = 0 002 Other results of the clinical trial indicate a significant increase in the total number of antral follicle count AFC p = 0 006 The results of the in vitro assessment in cumulus cell culture showed that in the non treatment group of PCO women, the mRNA expression of ADR α1 was higher than the control group P value
کلیدواژهها
نویسندگان
Farideh Zafari Zangeneh
Associate Professor of Reproductive Health Research Center, Tehran University of Medical Sciences, Tehran, Iran
Samad Muhammadnejad
Assistant professor of Cell Based Therapies Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences
Mohammad Mehdi Naghizadeh
Coach of Non proliferative Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran
Maryam Sarmast Shoushtari
Ph D student of Bio material Engineering, Chemical and Environmental Engineering Department, Engineering Faculty, Universiti Putra Malaysia,۴۳۴۰۰
Masoumeh Masomi
Ph D student in Medical Genetics, Faculty of Basic Sciences, Biology Group, Islamic Azad University, North Branch, Tehran, Iran
شیوه ارجاع
Zafari Zangeneh, Farideh and Muhammadnejad, Samad and Naghizadeh, Mohammad Mehdi and Sarmast Shoushtari, Maryam and Masomi, Masoumeh,1400,The first report of Clonidine invivo/invitro effects as a new pharmacological strategy in the infertile women with polycystic ovary syndrome,Fifth International Conference on New Findings in Midwifery, Obstetrics, Gynecology and Infertility
ارائهشده در
مجموعه مقالات پنجمین کنفرانس بین المللی یافته های نو در مامایی، زنان، زایمان و نازایی20 آبان 1400