چکیده مقاله
There is an obvious relationship between fertilizing capacity of sperm and with the normal morphology, quality chromatin and motility of sperm It is well known that thyroid hormones are the major regulators of testicular function A correlation was found between the hypothyroidism and sperm damages We studied the effects of hypothyroidism on sperm morphology, chromatin quality and motility In this study, 20 male mice were divided into the control and the hypothyroid group that received 0 05% 6 n propyl 2 thiouracil PTU for 35 days Sperm morphology with Papanicolaou staining and sperm chromatin quality with both Aniline Blue AB and Toluidine blue TB staining were assessed As well as, immunohistochemistry and real time PCR were done to evaluate the cation sperm channel Catsper genes changes A significant increase in the sperm chromatin condensation was found in the hypothyroid mice comparison to the control mice p
کلیدواژهها
نویسندگان
Fatemeh Alipour
Department of Anatomy and Cellular Biology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Mehdi Jalali
Department of Anatomy and Cellular Biology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Mohammad Reza Nikravesh
Department of Anatomy and Cellular Biology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Alireza Fazel
Department of Anatomy and Cellular Biology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Mojtaba Sankian
Bou Ali Research Institute, Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Elnaz khordad
Department of Anatomy and Cellular Biology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
شیوه ارجاع
Alipour, Fatemeh and Jalali, Mehdi and Nikravesh, Mohammad Reza and Fazel, Alireza and Sankian, Mojtaba and khordad, Elnaz,1400,Assessment of sperm morphology, chromatin integrity and Catsper genes expression in hypothyroid mice,Sixth International Conference on New Findings in Midwifery, Obstetrics, Gynecology and Infertility
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