چکیده مقاله
Endometriosis is a chronic inflammatory disease associated with the growth and proliferation of endometrial like tissues outside the uterus Although the exact etiology and mechanism of the pathogenesis of the disease have not been fully elucidated, the immune system cells and the mediators produced by them can be named as effective factors in the onset and progression of the disease Abundant production of inflammatory mediators by neutrophils and macrophages and reduced cytotoxicity of defined cells promote endometriosis at the early stages of the disease Following an increase in the inflammation of the environment, the body takes compensatory mechanisms to reduce inflammation and establish homeostasis For this purpose, the body produces remodeling and anti inflammatory factors leading to slow conversion of the inflammatory environment into a non inflammatory environment with proliferative and immunosuppressive properties Environmental conditions induce M2 macrophages, TH2 cells, and Tregs differentiation, promoting disease progression by producing angiogenic and immunosuppressive factors However, the exact molecular mechanism involved in changing inflammatory to non inflammatory conditions is not yet fully understood In this study, we attempted to review studies on the role of the immune system in endometriosis to better understand the pathogenesis of endometriosis
کلیدواژهها
نویسندگان
Maryam Zare Moghaddam
Reproductive Immunology Research Center, Shahid Sadoughi University of Medical Sciences,
Hossein Ansariniya
Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Seyed Mohammad Seifati
Reproductive Immunology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Fateme Zare
Reproductive Immunology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Farzaneh Fesahat
Reproductive Immunology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
شیوه ارجاع
Zare Moghaddam, Maryam and Ansariniya, Hossein and Seifati, Seyed Mohammad and Zare, Fateme and Fesahat, Farzaneh,1400,Immunopathogenesis of endometriosis; an overview of the role of innate and adaptive immune cells and their mediators,Sixth International Conference on New Findings in Midwifery, Obstetrics, Gynecology and Infertility
ارائهشده در
مجموعه مقالات ششمین کنفرانس بین المللی یافته های نو در مامایی،زنان ،زایمان و نازایی19 اسفند 1400