چکیده مقاله
Thermal conformational changes in human serum albumin HSA are currently investigated with a 10 mm phosphate buffer, at pH = 7 via circular dichroism CD and UV spectroscopy The results showed that temperatures in the range of 25oC to 55oC induce a reversible structural change in the HSA structure HSA phase transition related to physiological and pathological conditions of the body, especially fever The conformational change observed in the HSA is accompanied by a slight conversion of its secondary structure Acetaminophen is a papular pain killer, and HSA is used as a carrier of the drug Hence, acetaminophen can interact with HSA In this study of HSA acetaminophen interaction shows that the effects of acetaminophen on the structure of HSA, prevent its phase transition HSA acetaminophen interaction has led to stabilization This interaction is associated with 8 times the kJ / mol free energy change Structural changes in HSA due to its interaction with acetaminophen can be considered as a side effect of drugs and it may affect protein function
کلیدواژهها
نویسندگان
Fatemeh Astaraki
Tehran University of Research Sciences
شیوه ارجاع
Astaraki, Fatemeh,1401,Acetaminophen effects on human serum albumin (HSA),7th International Conference on New Findings in Midwifery, Obstetrics, Gynecology and Infertility
ارائهشده در
مجموعه مقالات هفتمین کنفرانس بین المللی یافته های نو در مامایی،زنان ،زایمان و نازایی10 تیر 1401