چکیده مقاله
Human papillomavirus is one of the leading causes of urogenital cancers especially cervicalcancer and plays a significant role in cancer related death in the developing countries Persistedinfection with high risk types of HPV is considered as main cause of cervical carcinogenesis Micro RNAs are a group of small non coding RNAs of 18 25 nucleotides capable of posttranscriptionalgene silencing and participated in the fundamental cellular and molecularmechanism, e g cell proliferation, differentiation, migration, cardiovascular andneurodegenerative diseases, and development and progression of cancer Recently, studies have focused on the role of miRNAs in tumorigenesis processes and found thatmiRNAs could play a dual role Oncogenic miRNAs that are upregulated during tumorigenesiscan promote cell proliferation and dedifferentiation, while inhibiting apoptosis On the otherhand, tumor suppressor miRNAs, downregulated during tumor development This study aimed toreview studies that have investigated differential expression of miRNAs in HPV based cervicalcancer and evaluate the role of miRNAs in outcomes of HPV infection A group of miRNAs are found to be upregulated in cervical cancer cell lines and tissues, and theother group, downregulated In conclusion, the data highlighted the expression and function offour extensively studied miRNAs Over expression of miR 21 and miR 9a introduced them asoncomiRs, while downregulation of miR 34a and miR 29 confirmed their protective role astumor suppressor miRNAs in cervical cancer development and progression Altogether,differential expression of miRNAs can be helpful in determination of molecular diagnostic andprognostic markers Also, they can be considered as good targets for therapy purposes
کلیدواژهها
نویسندگان
Solmaz Moniri Javadhesari
Assistant Professor, Department of Cellular and Molecular Biology, Faculty of Basic Sciences, Azarbaijan Shahid Madani University, Tabriz,Iran
Mohaddeseh Koohi
MSc, Department of Cellular and Molecular Biology, Faculty of Basic Sciences, Azarbaijan Shahid Madani University, Tabriz, Iran
شیوه ارجاع
Moniri Javadhesari, Solmaz and Koohi, Mohaddeseh,1401,Differential Expression of miRNAs in HPV-Based Carcinogenesis of Cervix; Oncogenic miRNAs Versus Tumor Suppressor miRNAs,7th International Conference on New Findings in Midwifery, Obstetrics, Gynecology and Infertility
ارائهشده در
مجموعه مقالات هفتمین کنفرانس بین المللی یافته های نو در مامایی،زنان ،زایمان و نازایی10 تیر 1401