چکیده مقاله
Purpose Despite the high risk of cardiovascular diseases in women with polycystic ovary syndrome PCOS , fewer studies have addressed the improvement of cardiometabolic status of these patients This study was conducted with the aim of investigating the effects of synbiotic containing spore forming Bacillus coagulans on cardiometabolic indicators including lipid profile, C reactive protein CRP and atherogenic indices Methods In the present clinical trial, 72 women with polycystic ovaries were randomly supplemented with either 2 grams of synbiotic sachet n = 26 or placebo n = 26 , plus lifestyle modification for 12 weeks Fasting blood samples were taken at the beginning and end of the intervention Findings A significant reduction was detected in CRP in the synbiotic, compared with placebo 0 12 ± 9 57 vs 0 008 ± 4 69, P = 0 030 No significant differences in mean changes of lipid profile and atherogenic indices were seen between the two groups Although the estimated mean changes in atherogenic indices in the synbiotic group showed a greater reduction than the placebo group, but no significant differences were observed Conclusion Despite a significant reduction in inflammation, synbiotics provide no additional cardiometabolic benefit for lifestyle modification in patients with PCOS
نویسندگان
Zahra Hariri
Clinical Nutrition and Dietetics Department,Faculty of Nutrition Sciences and Food Technology, NationalNutrition and Food Technology Research Institute,Shahid Beheshti University of Medical SciencesTehran, Iran
Zahra Yari
Department of Nutrition Research, National Nutrition andFood Technology Research Institute, Faculty of NutritionSciences and Food Technology, Shahid Beheshti University ofMedical Sciences,Tehran, Iran
Golbon Sohrab
Clinical Nutrition and Dietetics Department,Faculty of Nutrition Sciences and Food Technology, NationalNutrition and Food Technology Research Institute,Shahid Beheshti University of Medical SciencesTehran, Iran
Sedighe Hoseini
Department of Obstetrics and Gynecology, PreventativeGynecology Research Center,Shahid Beheshti University of Medical Sciences,Tehran, Iran
شیوه ارجاع
Hariri, Zahra and Yari, Zahra and Sohrab, Golbon and Hoseini, Sedighe,1402,Impacts of synbiotic containing Bacillus coagulans (GBI-30) on the lipid profile, C-reactive protein (CRP) and atherogenic indices of patients with polycystic ovary syndrome: A Triple-Blinded, Randomized, Placebo-Controlled Study,The 10th International Conference on New Findings in Obstetrics, Women, Childbirth and Infertility
ارائهشده در
مجموعه مقالات دهمین کنفرانس بین المللی یافته های نو در مامایی، زنان، زایمان و نازایی23 تیر 1402