چکیده مقاله
Objectives: Dysfunction of the thyroid gland has a negative effect on the male reproductive system Studies also show that extracellular matrix ECM components play an essential role in testicular development and function In Hypothyroidism, there is a significant disruption in the ECM structure of mammalian tissues Also, notable changes have been reported in the germ cell population under hypothyroid state This study aimed to investigate the relationship between ECM proteins and Apoptosis of testicular germ cells due to Hypothyroidism Materials and Methods:In the present experimental study, 20 male Balb/C mice were divided into control and hypothyroid groups Hypothyroid group was received 0 05% 6 n propyl 2 thiouracil PTU through drinking water for 35 days After confirmation of hypothyroidism, Real Time PCR, immunohistochemistry, Periodic Acid Schiff PAS staining, TUNEL assay, and biochemical measurements were performed Results: Laminin α5 and collagen IV mRNA levels were upregulated in the hypothyroid group compared to the controls p
کلیدواژهها
نویسندگان
Fatemeh Alipour
Department of Anatomy and Cellular Biology, Faculty of Medicine, Mashhad University ofMedical Sciences, Mashhad, Iran
Mehdi Jalali
Department of Anatomy and Cellular Biology, Faculty of Medicine, Mashhad University ofMedical Sciences, Mashhad, Iran
Mohammad Reza Nikravesh
Department of Anatomy and Cellular Biology, Faculty of Medicine, Mashhad University ofMedical Sciences, Mashhad, Iran
Alireza Fazel
Department of Anatomy and Cellular Biology, Faculty of Medicine, Mashhad University ofMedical Sciences, Mashhad, Iran
Mojtaba Sankian
Bou Ali Research Institute, Immunology Research Center, Mashhad University of MedicalSciences, Mashhad, Iran
Elnaz Khordad
Department of Anatomy and Cellular Biology, Faculty of Medicine, Mashhad University ofMedical Sciences, Mashhad, Iran
شیوه ارجاع
Alipour, Fatemeh and Jalali, Mehdi and Nikravesh, Mohammad Reza and Fazel, Alireza and Sankian, Mojtaba and Khordad, Elnaz,1402,The Relationship between Extracellular Matrix Proteins and Germ Cells Apoptosis in Balb/C Mouse Testis following Experimental Hypothyroidism Running title: Hypothyroidism on ECM and germ cells apoptosis of testis,The 10th International Conference on New Findings in Obstetrics, Women, Childbirth and Infertility
ارائهشده در
مجموعه مقالات دهمین کنفرانس بین المللی یافته های نو در مامایی، زنان، زایمان و نازایی23 تیر 1402