چکیده مقاله
Sperm DNA Fragmentation Index SDFI has been proposed as a candidate test forthe assessment of sperm integrity in assistedreproductive technologies It has been assumed thatdamage to the sperm chromatin is associated withdetrimental reproductive outcomes, but the resultsof different studies are controversial The objectiveof our study was to investigate whether spermDNA fragmentation testing has a prognostic valuefor Intra Cytoplasmic Sperm Injection ICSI Material and Methods: This was aretrospective cohort study conducted at Kamaliinfertility center SDFI was measured throughspecial kits based on Halo test assay on the freshsemen sample presented on oocyte puncture day incouples undergoing ICSI treatment Thegeneralized estimating equation GEE model andmultivariable model were used to analyse theprobability of clinical pregnancy and live birth rate LB , respectively ROC analysis was carried out todetermine an SDF cut off Results: There was an inverse relationshipbetween SDF in the ejaculate of the therapeuticsemen sample and fertility outcomes p = 0 02 aswell as LB p = 0 04 The ROC analysis proposeda cut off of 17 5% as the best compromise betweensensitivity and specificity in the diagnostic SDFIfor live birth; however, the test diagnostics are low,with an AUC of 0 576 Conclusion: Overall, this study strengthens thehypothesis of an inverse relationship between SDFIand LB Furthermore, SDFI taken together withother clinical characteristics might provide moreinsight into male reproductive potential andpredicting ICSI outcomes Couples with SDF ≥17 5% in the therapeutic semen sample reduce thechance of LB that anticipate your paper as onepart of the entire proceedings, and not as anindependent document Please do not reviseany of the current designations
کلیدواژهها
نویسندگان
Mitra Rahimi Fathkouhi
M sc of Developmental Biology, Alborz University ofMedical Sciences, Kamali infertility center
Samaneh Sadat Hoseini Quchani
Assistant Professor of Reproductive Biology,Department of Obstetrics and GynecologyAlborzUniversity of Medical Sciences, Kamali
شیوه ارجاع
Rahimi Fathkouhi, Mitra and Hoseini Quchani, Samaneh Sadat,1403,The Investigation of the relationship between Sperm DNAFragmentation index and outcomes of Intra-CytoplasmicSperm Injection in couples with unexplained or mild maleinfertility,13th International Conference on New Findings in Midwifery, Women, Maternity and Infertility
ارائهشده در
مجموعه مقالات سیزدهمین کنفرانس بین المللی یافته های نو در مامایی، زنان ،زایمان و نازایی19 مرداد 1403