چکیده مقاله
Treatment with USCs improved bladder compliance and maximal voiding stress decreased end filling stress and voided volume, reinforced detrusor contractility, and extended sensitivity to carbachol in PBO rats These changes had been related to a discount in collagen deposition withinside the extracellular matrix and a discount in molecular apoptosis Alterations in miRNA and mRNA expression stages withinside the bladder of pBO rats with and without USCs had been observed Bioinformatics evaluation of those changes can also additionally assist in higher recognition of the molecular mechanisms underlying the consequences of USCs in PBO rats miR 142 and miR 9a can also additionally play regulatory roles thru anti inflammatory, anti apoptotic, and antifibrotic consequences Although the mechanisms with the aid using which those consequences arise have now no longer been completely elucidated, USCs can also additionally exert their advantages thru necroptosis and cytokine cytokine receptor interplay signaling pathways USCs function as a beneficial non invasive molecular supply for sickness modeling with excessive proliferation and differentiation abilities, and the improvement of UPSC/UiNSC primarily based totally era holds widespread capability for scientific packages in customized medicine For a long time period healing capability, efficacy, and protection of gene edited UiNSCs or neural organoids want to be significantly evaluated in pre scientific rodent fashions and big animal fashions that greater intently mimic the neuropathological capabilities of humans The application of iPSCs and USCs may be beneficial for predicting drug reactions and assessing environmental sickness triggers in neuromuscular and neurodegenerative diseases The improvement of USCs and iPSCs primarily based totally era presents a brand new platform inside the area of sickness modeling and works in complementary ways, it's miles anticipated to advantage studies and scientific packages in personalized medicine
کلیدواژهها
نویسندگان
ALI JAFARI
Students of biomedical engineering BME Qom azad University ,
Seyedeh Masoumeh Sajjadi Manesh
Bachelor Graduated of biomedical engineering Qom azad University ,
Kimia Baghebani
Department of Biology, College of Basic Science, Kermanshah Branch, Islamic Azad University, Kermanshah, Iran
Yasna Bidmeshki
Department of biology, college of basic science,Kermanshah Branch,Islamic Azad university, Kermanshah, Iran
Samin Rahimi
Bachelor graduated of cellular and molecular biology , PhD student of Genetics, Faculty of Natural Sciences,University of Tabriz, East Azerbaijan, Iran
شیوه ارجاع
JAFARI, ALI and Sajjadi Manesh, Seyedeh Masoumeh and Baghebani, Kimia and Bidmeshki, Yasna and Rahimi, Samin,1401,Human urine-derived Stem Cells,10th International Conference on Health, Treatment and Health Promotion
ارائهشده در
مجموعه مقالات دهمین کنفرانس بین المللی بهداشت،درمان و ارتقای سلامت16 تیر 1401