چکیده مقاله
Numerous studies have been conducted to develop effective methods to combat cancer and reduce its severity One of the most promising approaches involves using potent chemotherapeutic agents that minimize damage to healthy cells Scientists have also explored materials capable of distinguishing between healthy and cancerous cells and responding accordingly By utilizing these differences, researchers aim to design materials that can release antitumor drugs specifically at tumor sites One such distinguishing factor is the difference in oxygen levels between normal and cancerous tissues, leading to hypoxia In this research, a methoxy poly ethylene glycol azobenzene poly ethylene succinate mPEG Azo PES copolymer was synthesized using a one pot method To investigate the structure of the polymer nanoparticles, Fourier transform infrared FT IR as well as proton nuclear magnetic resonance H NMR measurements were employed to confirm the chemical structure of the materials The results of the investigation indicated that these polymer nanoparticles have potent applicability as drug release agent in hypoxic tumor environments This strategy offers a targeted approach that could reduce side effects on healthy tissues and contribute to more selective cancer therapies
کلیدواژهها
نویسندگان
Sina Nasiri
Faculty of Chemical & Petroleum Engineering, University of Tabriz, Iran; Polymer Research Laboratory, Faculty of Chemistry, University of Tabriz, Iran
Mahsa Molaei Nasr
School of Chemical Engineering, College of Engineering, University of Tehran, Iran
Sadaf Dameshghi
Faculty of Chemical & Petroleum Engineering, University of Tabriz, Iran
Reza Najjar
Faculty of Chemical & Petroleum Engineering, University of Tabriz, Iran
شیوه ارجاع
Nasiri, Sina and Molaei Nasr, Mahsa and Dameshghi, Sadaf and Najjar, Reza,1404,Polyethylene Succinate-Based Polymeric Nanoparticles Bearing Azobenzene Moieties as Potential Agents for Hypoxia-Targeted Cancer Treatment,Fourth International Congress for Chemical Engineering and Petroleum Industry students,Tehran
ارائهشده در
مجموعه مقالات چهارمین کنگره بین المللی دانشجویان مهندسی شیمی و صنعت نفت29 آبان 1404 · تهران