چکیده مقاله
Objective : Negative symptoms treatment of schizophrenia has remained unsatisfactory, whilst positive symptoms managed more effectively In this regard the clinicians trying to find more effective combination drugs as monotherapy or augmentation therapy Objectives: In this study aimed to assess the efficacy of ondansetron augmentation therapy on negative symptoms of schizophrenia patients Methods: This is a parallel randomized clinical trial conducted on 50 schizophrenia patients, The participants allocated to ondansetron augmentation and placebo groups The negative symptoms measured with Positive and Negative Syndrome Scale PANSS in 0th, 4th, 8th and 12th weeks Results: Of 78% of patients were males The mean age of patients was 35 7 7 9 and 38 2 9 1 for intervention and control groups There was not between group significant differences respect to age, sex, duration and onset age of disease and PANSS baseline score The analysis results revealed significant decline of negative symptoms in both study groups declining negative symptom scores 21 7 to 9 2 in intervention group, 22 8 to 12 0 for placebo group without significant difference between them F=2 19, P=0 14 Conclusions: The augmentation therapy with ondansetron on schizophrenia patients had not enough efficacy, compare to placebo More studies with sophisticated approaches such as factorial design with using different drugs on similar patients is recommended
کلیدواژهها
نویسندگان
Afshin Ahmadvand
Kashan University of Medical Sciences
Zahra Sepehrmansh
Kashan University of Medical Sciences
Alireza Motshaker
Kashan University of Medical Sciences
شیوه ارجاع
Ahmadvand, Afshin and Sepehrmansh, Zahra and Motshaker, Alireza,1401,Effect of Ondansetron augmentation therapy on schizophrenia symptoms: A double-blinded randomized clinical trial.,10th International Conference on Health, Treatment and Health Promotion
ارائهشده در
مجموعه مقالات دهمین کنفرانس بین المللی بهداشت،درمان و ارتقای سلامت16 تیر 1401