چکیده مقاله
Background and aim: Colorectal cancer is a multifactorial disease caused by the accumulation of somatic mutations in genes Various mutations on KRAS proto oncogene has been found in patients with colorectal cancer In this study we investigated prevalence of KRAS mutations in patients with colorectal cancer and in West Azerbaijan province, Iran Methods: Genomic DNA was extracted from colorectal tumor tissue obtained from 51 patients with primary colorectal cancer Direct sequencing method was used for determining location and type of KRAS gene mutations Finally, the obtained data were analyzed statistically Results: The prevalence of KRAS gene mutation was 1 96% 1 in 51 patients The identified mutation was p Ala146Thr rs121913527 on exon 4 of KRAS in a male patient The female did not carry any KRAS gene mutations Conclusion: A higher age distribution ratio than the early onset of colorectal cancer in Iran requires attention to screening and prevention programs in the younger age group in Iran There is also a growing need for large scale molecular genetic studies in larger populations and different geographical areas
کلیدواژهها
نویسندگان
Ali Vahabi
Department of Genetics and Immunology, Faculty of medicine, Urmia University of Medical Sciences, Urmia, Iran
شیوه ارجاع
Vahabi, Ali,1401,KRAS mutations in patients with colorectal cancer,10th International Conference on Health, Treatment and Health Promotion
ارائهشده در
مجموعه مقالات دهمین کنفرانس بین المللی بهداشت،درمان و ارتقای سلامت16 تیر 1401