چکیده مقاله
Introduction: Leukemia is a cancer of the hematopoietic tissues of the body, including the bone marrow and lymphatic system The tyrosine kinase 3 FLT3 gene, which encodes a membrane bound receptor tyrosine kinase, plays an essential role in normal hematopoiesis FLT3 mutations are considered high risk factors in leukemia This gene is overexpressed in leukemia and patients with high expression of FLT3 simultaneously express high levels of leukemic oncogenes Therefore, high expression of FLT3 is a risk factor in leukemia FLT3 gene is specifically overexpressed in acute lymphoid and myeloid leukemia ALL and AML 1 A large number of MicroRNAs are tumorigenic, while others have tumor suppressor effects Previous studies showed that the expression of miR 150 is decreased in patients with AML, and this miRNA acts as a tumor suppressor in AML patients 2 Material and methods: First, using the Enrichr site, the FLT3 gene was selected as a gene involved in leukemia FLT3 was selected as the target gene for the hsa miR 150 5p by the miRTarBase section of this site By selecting FLT3 as the target gene and hsa miR 150 5p as the miRNA, the results of their interaction were investigated in the miRwalk database The findings related to the interaction of these two sections can be observed in the miRTarBase Results: According to the findings of the miRTarBase site, hsa miR 150 5p by targeting the 3'UTR region of the FLT3 gene and with the help of the RISC complex leads to the suppression of the mRNA translation of the target gene hsa miR 150 5p sequence binds to nucleotides 16 to 37 of the target mRNA gene Conclusion: According to previous studies, bioinformatic predictions, the oncogenic role of the FLT3 gene, and the function of the microRNAs negative regulation, it is expected that the expression of the hsa miR 150 5p will decrease, and then, the expression of FLT3 gene will increase For this reason, it is predicted that hsa miR 150 5p has an anti tumor function and the decrease in the expression of this miRNA leads to an increase in the expression of the FLT3 gene, tumor growth, and the development of malignancy in leukemia
کلیدواژهها
نویسندگان
Elham Talebi
Department of Genetics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic AzadUniversity, Tehran, Iran
Bahare abdollahi
Student Research Committee, School of Medical, Iran University of Medical Sciences, Tehran, Iran,
Armin Yahyaei
School of Medicine, Iran University of Medical Sciences, Tehran, Iran,
Zahra Ghasemi
Bachelor of cellular and molecular_ Genetics, Department of Biology, Basic Science Faculty, Islamic AzadUniversity, Shahrekord, Iran
Shakila Omid
Bachelor of cellular and molecular_ Genetics, Department of Biology, Basic Science Faculty, Islamic AzadUniversity, Shahrekord, Iran,
Pouyan Asadi
Medical Cellular & Molecular Research Center, Golestan University of Medical Sciences, Gorgan, Iran,
شیوه ارجاع
Talebi, Elham and abdollahi, Bahare and Yahyaei, Armin and Ghasemi, Zahra and Omid, Shakila and Asadi, Pouyan,1401,Study of the relationship between FLT3, hsa-miR-150-5p, and the progression of malignancy in patients with leukemia,10th International Conference on Health, Treatment and Health Promotion
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