چکیده مقاله
Introduction: Most colorectal cancers are due to aging and lifestyle factors, and a small number of cases are caused by genetic disorders 1 There are many genes that cause colorectal cancer such as APC, TP53, KRAS, etc Adenomatous polyposis Coli APC is a protein negative regulator that regulates beta catenin concentrations and interacts with E cadherin, which is involved in cell adhesion APC is classified as a tumor suppressor gene, preventing the uncontrolled growth of cells that may result in cancerous tumors 2 Material and methods: First, by examining the types of cancers based on the prevalence and related research on the Genomic Data Commons GDC Data Portal/Atlas Cancer website, colorectal cancer was selected Using the DisGeNET database, potential genes were obtained based on Digital Sequence Information on Genetic Resources DSI , PLI Probability of being Loss of function Intolerant , and score filters The genes were evaluated based on their P values The role of the APC gene was examined in the Tumor Portal database and some filters such as gender, age, ethics, vital status, and types of mutations were applied Finally, colorectal cancer was investigated in terms of clinical characteristics, the rate of affected people, and the relationship between genotype and genotype of potential genes through the Genotype Phenotype Integrator/Phenotype Selection dbGap and Online Mendelian Inheritance in Man OMIM website Results: According to the DisGeNET website, the disease specificity index DSI for APC was low and this shows high specificity for this cancer The score for APC was 1 representing a high degree of association between the gene and the disease, and for PLI was 1, which indicates that the loss of function of this gene is dangerous for humans The tumor portal website revealed 173/233 patients, i e 78% of patients with mutations in this gene Conclusion: The APC gene is more frequent than other genes, and the survival rate for people who carry mutations in the APC gene is less likely to survive than for those who do not Men are more likely than women to develop colorectal cancer, and most of these cancers are primary tumors The survival rate for colorectal cancer is relatively high and only a small number of people die
کلیدواژهها
نویسندگان
Maryam Motallebinezhad
Department of Molecular and Cellular Biology, Faculty of Basic Sciences, Mazandaran University, Babolsar, Iran,
Armin Yahyaei
School of Medicine, Iran University of Medical Sciences, Tehran, Iran,
Mehrnoush AshjaMahdavi
Research assistant at UTU university of health and science,
Pouyan Asadi
Medical Cellular & Molecular Research Center, Golestan University of Medical Sciences, Gorgan, Iran,
شیوه ارجاع
Motallebinezhad, Maryam and Yahyaei, Armin and AshjaMahdavi, Mehrnoush and Asadi, Pouyan,1401,The role of the APC gene in Colorectal Cancer,10th International Conference on Health, Treatment and Health Promotion
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