چکیده مقاله
Background and Aim: Recurrent pregnancy loss RPL is a disease defined as two or more failed pregnancies Affecting 2% 5% of couples trying to conceive, it has a significant psychological toll on the couples So far, various etiologies have been reported including uterine factors, antiphospholipid syndrome, inherited thrombophilia, endocrine and genetic factors Growing evidence is being collected showing contribution of male factor, especially DNA Fragmentation Index DFI In this study, we investigated the main male factors associated with RPL in an Iranian population We chose to evaluate subjects' karyotype, sperm parameters and DFI as these are the tests that have been proved to be relevant in the matter of infertility Methods: To be eligible, female partner first underwent gynecologic evaluation to exclude female factors contributing to RPL, anatomical abnormalities, thyroid and reproductive hormone disturbances, abnormal rheumatologic diseases markers and the male partner must have been shown to not have hormonal disturbances and anatomical anomalies in screening In a population of 232 cases with a history of RPL, we took samples to determine karyotype, perform semen analysis according to WHO 2010 guidelines and sperm chromatin dispersion SCD test for determining DFI Results: Results of semen analysis was compared with normal values as provided by WHO 2020 guidelines 53 22 8 % of the subjects showed abnormal sperm counts 173 74 5 % had abnormal motility and 130 56 % demonstrated abnormal morphology DNA fragmentation testing resulted in 63 abnormal cases which is 27 1 % of the subjects 3 subjects had abnormal karyotypes of : 46XY inv 9 p12q13 , 45XY der 13q : 149 t 13q10 : 14q10 Balanced and Roberstsonian translocation , 46XY t 5:7 p13 , p15 Conclusion: As with the cumulating evidence of the relationship between DFI and RPL our study suggests that along with semen analysis and karyotyping, measuring DFI should also be adopted into standard practice when dealing with couples who experience the condition
کلیدواژهها
نویسندگان
Amin Attar
Medical student, Iran University of Medical sciences, Tehran, Iran
Kimiya Kheradmand
Dentistry student, Dentistry Faculty, Debrecen University, Debrecen, Hungary
Negin Kheradmand
Dentist, Private Dentistry Clinic, Ahvaz, Iran
Alireza Kheradmand
Urologist, Urology Department, Jundishapur Ahvaz University of Medical Sciences, Ahvaz Iran
شیوه ارجاع
Attar, Amin and Kheradmand, Kimiya and Kheradmand, Negin and Kheradmand, Alireza,1401,Male factor in recurrent pregnancy loss,The 11th International Conference on Health, Treatment and Health Promotion
ارائهشده در
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