چکیده مقاله
Tumor heterogeneity encompasses the inherent diversity observed among cancerous tissues, manifesting at multiple biological levels This variation may appear within a single tumor mass, across different anatomical sites in the same patient, or between individuals diagnosed with the same tumor subtype Tumors exhibiting heterogeneity demonstrate distinct biological, morphological, phenotypic, and genotypic attributes As malignant cells progress over time, they often acquire enhanced heterogeneity through genetic mutations, largely driven by genomic instability, and adapt to the pressures of diverse treatment modalities Genetically, it includes alterations such as single nucleotide variants and copy number changes; epigenetically, it involves modifications like DNA methylation patterns and fluctuations in gene expression; and at the protein level, it is reflected in differential proteomic profiles These heterogeneity layers contribute to the dynamic nature of cancer evolution and therapy response It is commonly linked to diminished therapeutic efficacy, increased resistance to treatment protocols, and generally poorer prognoses for patients This complexity can hinder the development of uniformly effective interventions and challenge precision medicine strategies In this paper, we aim to define and contextualize the concept of tumor heterogeneity, classify its diverse manifestations, and examine its influence on cancer therapy, with particular emphasis on the emergence of therapy resistance
کلیدواژهها
نویسندگان
Pouyan Asadi
Medical Cellular and Molecular Research Center, Golestan University of Medical Sciences, Gorgan, Iran
Maryam Nabizadeh
Department of Obstetrics and Gynecology, School of Medicine, Shahid Beheshti University of Medical Sciences, Taleghani Hospital, Tehran, Iran
Omyd Dorodi
Department of Medical Science, Shahrood branch, Islamic Azad University, Shahrood, Iran
Rabee Movagharnia
Department of Genetics and Biotechnology, School of Biological Sciences, Varamin Pishva Branch, Islamic Azad University, Varamin, Iran
Elmira Keramatfar
Medical faculty of Friedrich Schiller Universität Jena, Germany
شیوه ارجاع
Asadi, Pouyan and Nabizadeh, Maryam and Dorodi, Omyd and Movagharnia, Rabee and Keramatfar, Elmira,1404,Tumor Heterogeneity as a Driver of Cancer Complexity,20th International Conference on Health, Treatment and Health Promotion
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