چکیده مقاله
Objective: Ischemic stroke being the most prevalent type of stroke, affecting the vulnerable hippocampus Understanding the interplay between long term stress and stroke related cognitive dysfunction is crucial, as chronic stress exacerbates oxidative damage and may hinder recovery Therefore, this study aimed to investigate the levels of oxidative stress in hippocampal tissue following long term stress exposure in a rat model post stroke Methods: This study utilized 24 male rats The rats were randomly assigned to four groups: a sham group, a long term stress model LSM group, a control group stroke induction , and a long term stress with stroke induction LSC group The long term stress protocol involved daily immobilization in transparent plexiglass restrainers for four hours over 15 consecutive days Following 21 days post surgery, biochemical assessments included measuring malondialdehyde MDA levels using a thiobarbituric acid assay and total thiol SH concentrations in the hippocampus using the DTNB reagent Results: The control, LSM, and LSC groups exhibited significantly higher MDA levels compared to the sham group p
کلیدواژهها
نویسندگان
Amirhossein Rabiei Rad
Faculty of Health Sciences, Department of Physiotherapy and Rehabilitation, Tokat Gaziosmanpaşa University, Tokat, Turkey
Arman Abroumand Gholami
Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
شیوه ارجاع
Rabiei Rad, Amirhossein and Abroumand Gholami, Arman,1403,Long-Term Stress-Induced Neurological Deficits In Hippocampal Tissue Of Animals Following Stroke,6th International conference on Health, Educational Sciences and psychology
ارائهشده در
مجموعه مقالات ششمین کنفرانس بین المللی سلامت، علوم تربیتی و روانشناسی28 دی 1403