چکیده مقاله
Bioactive peptides 2 50 amino acids represent a transformative therapeutic class for colorectal cancer CRC , overcoming conventional treatment limitations through high specificity, multi pathway targeting, and favorable toxicity profiles These agents demonstrate sophisticated mechanisms, including: 1 epigenetic modulation YG 22 peptide altering 1,697 chromatin peaks , 2 apoptosis induction lactoferrin activated WTAP/m6A axis , 3 cell cycle arrest PepGAT/PepKAA, IC50 40 125 μM , and 4 anti angiogenesis VEGF/MMP 9 suppression Sourced from plants lunasin, IC50 ~80 μM , animals goat milk casein inducing 80 92% apoptosis , and microbes spirulina peptide YGFVMPRSGLWFR, 46 68% inhibition , their clinical translation is accelerating―exemplified by CBX 12 first pHLIP based conjugate entering Phase II and lunasin 3g/day efficacy in human trials Nanotechnology breakthroughs address delivery challenges LPK PTX nanoparticles , while AI leverages the DCTPep database 6,214 entries for rational design Paradigm shifting discoveries of IncRNA encoded peptides HOXB AS3, SRSP further expand the therapeutic landscape To fully realize their potential as precision CRC therapeutics, future development requires manufacturing scale up automated synthesis with ≥95% purity , combination therapies, and adaptive regulatory strategies
کلیدواژهها
نویسندگان
Elham Ansarian
Department of Food Science and Technology, Faculty of Agriculture, University of Tabriz, Tabriz, Iran
Mandana Bimakr
Department of Food Science and Engineering, Faculty of Agriculture, University of Zanjan, Zanjan, Iran
Ali Ganjloo
Elham Ansarian Department of Food Science and Technology, Faculty of Agriculture, University of Tabriz, Tabriz, IranMandana Bimakr Department of Food Science and Engineering, Faculty of Agriculture, University of Zanjan, Zanjan, Iran
شیوه ارجاع
Ansarian, Elham and Bimakr, Mandana and Ganjloo, Ali,1404,Transformative Advances in Bioactive Peptide Therapeutics for Colorectal Cancer: From Epigenetic Reprogramming to Clinical Translation,The Second International Congress of Cancer,Zanjan
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