چکیده مقاله
Background and Aim: Anticancer effects of androgens on colorectal cancer cells has been reported in clinical and experimental studies, however, few studies have been carried out on the anticancer effects of cortisol against colorectal cancer We exerted the present study to determine the cytotoxic effects of cortisol and testosterone on colorectal cancer HT29 cells in vitro Methods: In this laboratory – experimental study colon cancer HT29 cells were divided to control untreated group and groups exposed to different concentrations of cortisol, testosterone and “testosterone cortisol” Viability of cancer cells were measured using MTT assay method The data were analyzed using one way analysis of variance ANOVA Results: The results of this study indicated that higher concentrations of testosterone >125 μg/ml has cytotoxic effects on colon cancer cells with a dose dependent patter Treatment of colon cancer cells with different doses of cortisol 0 1, 1, 10, 100, 1000 and 10000 μg/ml did not show significant cytotoxic effects on colon cancer cells viability and treatment of the cells with 10000 μg/ml of cortisol with different testosterone concentrations indicated that cortisol prevents cytotoxic effects of higher testosterone concentrations >250 μg/m on colorectal cancer cells Conclusion: We have shown that despite cortisol, testosterone has cytotoxic effects on colorectal cancer cells Cortisol also can prevent anticancer effects of testosterone on colon cancer cells
کلیدواژهها
نویسندگان
Amin Sarkhoh
Department of Biology, Faculty of Basic Sciences, Hamedan Branch, Islamic Azad University, Hamedan, Iran
شیوه ارجاع
Sarkhoh, Amin,1399,Cortisol May Prevent Anticancer Effects of Testosterone on Colon Cancer (HT29) Cells in vitro,First International Conference on Management, Tourism and Technology
ارائهشده در
مجموعه مقالات اولین کنفرانس بین المللی مدیریت، گردشگری و تکنولوژی22 آبان 1399 · تهران