چکیده مقاله
Objective: The main aim of the present research work was to formulate fast dissolving tablets of Cimetidine by direct compression method and to evaluate the effect of synthetic super disintegrating agent on drug release pattern Methods: The fast dissolving tablets were prepared by using crospovidone, croscarmellose sodium, sodium starch glycolate as superdisintegrants 2, 4 and 6 %w/w , mannitol 20% and microcrystalline cellulose 44, 46 and 48 % w/w as a directly compressible vehicle All the prepared tablets were evaluated for hardness, friability, drug content uniformity, weight variation, disintegrating time, wetting time and in vitro drug release studies Results: All the prepared fast dissolving tablets formulations were within the Pharmacopoeial standards limits Based on in vitro drug release studies >90 % within 30 min , the optimised formulations were tested for the short term stability at 40 °C/75% RH for 3 mo and drug excipient interaction fourier transform infrared spectroscopy Conclusion: Hence, formulation prepared with 6 % w/w of crosspovidone and 44 % w/w of microcrystalline cellulose emerged as the overall best formulation >90% within 30 min compared to marketed product >70 % within 30 min Short term stability studies on the formulations indicated that there are no significant changes in drug content and in vitro drug release p
کلیدواژهها
نویسندگان
Mostafa Khajeh Dehaghani
Department of Research and Development farabi Pharmaceutical
رزومه علمی کاربران
درباره سیویلیکاتبلیغات در سیویلیکاآمار علمی ایرانتقویم علمی ایرانداده کاوی مقالاتطرح های پژوهشی
شیوه ارجاع
در صورتی که می خواهید در اثر پژوهشی خود به این مقاله ارجاع دهید، به سادگی می توانید از عبارت زیر در بخش منابع و مراجع استفاده نمایید: Khajeh Dehaghani, Mostafa,1404,Formulation And Evaluation of Cimetidine Fast Dissolving Tablets Using Synthetic Super Disintegrants,Fourth International Conference for Iranian Hygienics and Health Sciences Students,Tehran,https://civilica.com/doc/2636157
ارائهشده در
مجموعه مقالات چهارمین کنفرانس بین المللی دانشجویان بهداشت و علوم سلامت ایران30 بهمن 1404 · تهران