چکیده مقاله
Antiserum, traditionally derived from immunized animals and containing polyclonal antibodies, has been a cornerstone in diagnostics, therapeutics, and research for over a century 83 However, advancements in biotechnology have revolutionized antiserum production, shifting from conventional animal based methods to innovative techniques such as recombinant antibody engineering, phage display, single B cell cloning, and monoclonal antibody mAb production 1, 6 This systematic review synthesizes evidence from peer reviewed literature on these modern methods, evaluating their efficacy, scalability, ethical considerations, and applications in medicine A comprehensive search across databases like PubMed, Web of Science, and Scopus yielded 1,256 articles, of which 152 met inclusion criteria after screening Key findings highlight the superiority of recombinant methods in producing consistent, high affinity antibodies with reduced immunogenicity, particularly for therapeutic use 3, 15 Phage display and single B cell technologies enable rapid isolation of specific antibodies 9, 10 , while advances in polyclonal recombinant antibodies mimic natural immune responses 20 Challenges include high production costs and regulatory hurdles, but future directions point toward AI integration and plant based expression systems 29 This review underscores the transition to humane, efficient antiserum production, offering insights for researchers and clinicians
کلیدواژهها
نویسندگان
Amir Amirkhani
Student Research Committee Kerman University of Medical Sciences, Kerman, Iran
Hamidreza Farhadi Rad
Student Research Committee Jiroft University of Medical Sciences, Jiroft, Iran
رزومه علمی کاربران
درباره سیویلیکاتبلیغات در سیویلیکاآمار علمی ایرانتقویم علمی ایرانداده کاوی مقالاتطرح های پژوهشی
شیوه ارجاع
در صورتی که می خواهید در اثر پژوهشی خود به این مقاله ارجاع دهید، به سادگی می توانید از عبارت زیر در بخش منابع و مراجع استفاده نمایید: Amirkhani, Amir and Farhadi Rad, Hamidreza,1404,Modern Methods in Antiserum Production: A Systematic Review,Fourth International Conference for Iranian Hygienics and Health Sciences Students,Tehran,https://civilica.com/doc/2636161
ارائهشده در
مجموعه مقالات چهارمین کنفرانس بین المللی دانشجویان بهداشت و علوم سلامت ایران30 بهمن 1404 · تهران