چکیده مقاله
Mycobacterium tuberculosis and non tuberculous mycobacteria are intracellular pathogens that involve the lungs and upper respiratory system, causing acute or chronic respiratory tract infections The aim of this study is to comprehensively investigate the level of expression of Mir 302a/b in Mycobacterium tuberculosis and non tuberculous This study was a case control type and the results were compared between two groups of patients and healthy Samples were collected from 400 people suspected of Mycobacterium tuberculosis and non tuberculous mycobacterium infection during a one year period from patients referred to the National Tuberculosis Reference Laboratory of Masih Daneshvari Hospital, and after extracting Mir 302a/b, its expression was measured using the Real Time PCR method was investigated There was no significant difference in serum expression of Mir 302a/b gene in PPD negative subjects with symptoms, but in smear positive and PPD negative subjects, PPD positive and smear negative subjects, smear positive and PPD positive subjects, there was a significant increase in Mir 302a/b gene expression These results require more accurate diagnostic methods and confirm molecular methods in the diagnosis of Mycobacterium tuberculosis and non tuberculosis Mycobacterium; Because late diagnosis of infection can destroy the chance of effective treatment and endanger people's lives Also, considering the relationship between Mir 302a/b and this infection, Mir 302a/b inhibitors can also be used to treat the disease
کلیدواژهها
نویسندگان
Jafar Aghajani
Mycobacteriology Research Center MRC , National Research Institute of Tuberculosis and Lung Disease NRITLD , Shahid Beheshti University of Medical Sciences, Tehran, Iran
Parissa Farmia
Mycobacteriology Research Center MRC , National Research Institute of Tuberculosis and Lung Disease NRITLD , Shahid Beheshti University of Medical Sciences, Tehran, Iran
Saman Ayoubi
Mycobacteriology Research Center MRC , National Research Institute of Tuberculosis and Lung Disease NRITLD , Shahid Beheshti University of Medical Sciences, Tehran, Iran
Poopak Farmia
Mycobacteriology Research Center MRC , National Research Institute of Tuberculosis and Lung Disease NRITLD , Shahid Beheshti University of Medical Sciences, Tehran, Iran Department of Biotechnology, School of Advanced Technology in Medicine, Shahid Beh
Jalaledin Ghanavi
Mycobacteriology Research Center MRC , National Research Institute of Tuberculosis and Lung Disease NRITLD , Shahid Beheshti University of Medical Sciences, Tehran, Iran
Ali Akbar Velayati
Mycobacteriology Research Center MRC , National Research Institute of Tuberculosis and Lung Disease NRITLD , Shahid Beheshti University of Medical Sciences, Tehran, Iran
شیوه ارجاع
Aghajani, Jafar and Farmia, Parissa and Ayoubi, Saman and Farmia, Poopak and Ghanavi, Jalaledin and Velayati, Ali Akbar,1402,Comprehensive investigation of Mir-302a/b expression level in Mycobacterium tuberculosis and non-tuberculous,The first international conference of health and health sciences students of Iran,Tehran
ارائهشده در
مجموعه مقالات اولین کنفرانس بین المللی دانشجویان بهداشت و علوم سلامت ایران31 اردیبهشت 1402 · تهران