چکیده مقاله
The incidence of drug resistance in tuberculosis became significant and started to increase with the introduction of the first anti tuberculosis drug in the world in 1943 But unfortunately, following the widespread use of rifampin which began to be used in the 70s in the 20th century , multidrug resistant tuberculosis emerged in the world and quickly became a fundamental and threatening problem for the control of tuberculosis in many countries and the world Became The aim of this study is to investigate the serum level of interleukins P70 and P40 in patients with drug resistant tuberculosis Considering the importance of cellular immunity in drug resistant tuberculosis infection and disease, this study was conducted in order to find the predictive role of P70 and P40 in the diagnosis of drug resistant tuberculosis among symptomatic people who were admitted to the educational, research and treatment center for drug resistant tuberculosis and pulmonary diseases of Dr Masih Deneshvari Hospital Tehran, Iran referred, it was designed and implemented Serum levels of P70 and P40 were measured using ELISA technique Then, the determined amounts of cytokines were entered into the statistical software to clarify their relationship and predictive character in the diagnosis of drug resistant tuberculosis Using the Roc curve, this study succeeded in determining the cut off level for the serum concentration of P70 and P40 in the diagnosis of tuberculosis, with a sensitivity and specificity of 68% and 46%, respectively The serum level of P40 did not show any relationship with P70, nor did it show a reliable value in the diagnosis of drug resistant tuberculosis In this study, a logical relationship between drug resistant tuberculosis and higher serum P40 levels was seen, which shows the benefits of this test in solving laboratory limitations, along with the sputum test
کلیدواژهها
نویسندگان
Jafar Aghajani
Mycobacteriology Research Center MRC , National Research Institute of Tuberculosis and Lung Disease NRITLD , Shahid Beheshti University of Medical Sciences, Tehran, Iran
Parissa Farmia
Mycobacteriology Research Center MRC , National Research Institute of Tuberculosis and Lung Disease NRITLD , Shahid Beheshti University of Medical Sciences, Tehran, Iran
Saman Ayoubi
Mycobacteriology Research Center MRC , National Research Institute of Tuberculosis and Lung Disease NRITLD , Shahid Beheshti University of Medical Sciences, Tehran, Iran
Poopak Farmia
Mycobacteriology Research Center MRC , National Research Institute of Tuberculosis and Lung Disease NRITLD , Shahid Beheshti University of Medical Sciences, Tehran, Iran Department of Biotechnology, School of Advanced Technology in Medicine, Shahid Beh
Jalaledin Ghanavi
Mycobacteriology Research Center MRC , National Research Institute of Tuberculosis and Lung Disease NRITLD , Shahid Beheshti University of Medical Sciences, Tehran, Iran
Ali Akbar Velayati
Mycobacteriology Research Center MRC , National Research Institute of Tuberculosis and Lung Disease NRITLD , Shahid Beheshti University of Medical Sciences, Tehran, Iran
شیوه ارجاع
Aghajani, Jafar and Farmia, Parissa and Ayoubi, Saman and Farmia, Poopak and Ghanavi, Jalaledin and Velayati, Ali Akbar,1402,Examination of serum levels of interleukins P70 and P40 in patients with drug-resistant tuberculosis,The first international conference of health and health sciences students of Iran,Tehran
ارائهشده در
مجموعه مقالات اولین کنفرانس بین المللی دانشجویان بهداشت و علوم سلامت ایران31 اردیبهشت 1402 · تهران