چکیده مقاله
Members of the Mycobacterium tuberculosis complex are the causative agents of human tuberculosis In general, there are two types of tuberculosis including latent tuberculosis and active tuberculosis Latent tuberculosis infection means a condition in which a person is infected with Mycobacterium tuberculosis but does not have active tuberculosis disease and is without clinical and radiological findings Among the people suffering from this disease, only 10% of people infected with Mycobacterium tuberculosis show symptoms of the disease This problem shows the role of genetic factors in susceptibility to this disease The aim of this study is to investigate the promoter and polymorphism of the A10825 gene in latent tuberculosis This cross sectional descriptive study was conducted on 100 latent tuberculosis patients with positive PPD test and 100 healthy controls Single nucleotide polymorphisms in A10825 region were determined by PCR RFLP No significant difference was observed in the allelic sequence of A10825 regions between the sick and healthy subjects of the study p≥0 05 Also, there was no significant relationship between promoter gene polymorphism and A10825 polymorphism of susceptibility to latent tuberculosis Despite the lack of relationship between A10825 beta receptor gene polymorphisms and latent tuberculosis, due to the effective role of genetic factors in disease susceptibility, it is suggested to carry out more research on this matter
کلیدواژهها
نویسندگان
Jafar Aghajani
Mycobacteriology Research Center MRC , National Research Institute of Tuberculosis and Lung Disease NRITLD , Shahid Beheshti University of Medical Sciences, Tehran, Iran
Parissa Farmia
Mycobacteriology Research Center MRC , National Research Institute of Tuberculosis and Lung Disease NRITLD , Shahid Beheshti University of Medical Sciences, Tehran, Iran
Saman Ayoubi
Mycobacteriology Research Center MRC , National Research Institute of Tuberculosis and Lung Disease NRITLD , Shahid Beheshti University of Medical Sciences, Tehran, Iran
Poopak Farmia
Mycobacteriology Research Center MRC , National Research Institute of Tuberculosis and Lung Disease NRITLD , Shahid Beheshti University of Medical Sciences, Tehran, Iran Department of Biotechnology, School of Advanced Technology in Medicine, Shahid Beh
Jalaledin Ghanavi
Mycobacteriology Research Center MRC , National Research Institute of Tuberculosis and Lung Disease NRITLD , Shahid Beheshti University of Medical Sciences, Tehran, Iran
Ali Akbar Velayati
Mycobacteriology Research Center MRC , National Research Institute of Tuberculosis and Lung Disease NRITLD , Shahid Beheshti University of Medical Sciences, Tehran, Iran
شیوه ارجاع
Aghajani, Jafar and Farmia, Parissa and Ayoubi, Saman and Farmia, Poopak and Ghanavi, Jalaledin and Velayati, Ali Akbar,1402,Investigation of A10825 gene promoter and polymorphism in latent tuberculosis,The first international conference of health and health sciences students of Iran,Tehran
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مجموعه مقالات اولین کنفرانس بین المللی دانشجویان بهداشت و علوم سلامت ایران31 اردیبهشت 1402 · تهران