چکیده مقاله
Bacteria commonly use two component signal transduction pathways to couple environmental stimuli to adaptive responses Most species contain more than a dozen two component systems TCSs that regulate a wide variety of behaviors, including fundamental processes such as metabolism and motility in addition to specialized processes such as virulence and development This narrative, non systematic review provides an update on the two component signal transduction system in bacteria In this review, we retrieved 63 published papers about two component signal transduction system in bacteria from 1990 to 2020 and summarize the current understanding of the structural and functional features of all part that participate a two component signal transduction system The two component systems domains has been identified with statistical significance in multidomain proteins that participate in a variety of signal transduction processes The two component systems in bacteria differs from ‘input’ sensing domains and ‘output’ receiver domains homologues, and in receptor contexts is likely to act not as an adapter module, mediating association of signalling complexes, but rather as a sensor of conformational change and inhibitor of constitutive histidine kinase signalling Recognition that domains are widespread among prokaryotic signalling proteins should assist in the understanding of the molecular mechanisms that mediate the intricate regulation of prokaryotic membrane associated signalling arrays
کلیدواژهها
نویسندگان
Yousef Atefpour
Department of Medical Microbiology, School of Medicine, Alborz University Medical Sciences, Alborz, Karaj, Iran
Kimia Kazemi
Department of Medical Microbiology, School of Medicine, Alborz University Medical Sciences, Alborz, Karaj, Iran
Somayeh Yaslianifard
Associate Professor in Department of Medical Microbiology, Dietary Supplements & Probiotic Research Center and School of Medicine, Alborz University Medical Sciences,Alborz, karaj, Iran
شیوه ارجاع
Atefpour, Yousef and Kazemi, Kimia and Yaslianifard, Somayeh,1402,Two Component System in Bacteria,The first international conference of health and health sciences students of Iran,Tehran
ارائهشده در
مجموعه مقالات دومین کنفرانس بین المللی دانشجویان بهداشت و علوم سلامت ایران30 بهمن 1402 · تهران