چکیده مقاله
Background: Coronavirus COVID 19 has affected more than 218 million individuals globally, leading to >4 million deaths Vitamin D Vit D has immune modulating effects that modify the inflammatory response This study aimed to evaluate the effects of high dose Vit D supplementation on inflammatory markers in COVID 19 Method: This double blinded randomized clinical trial was conducted on 140 hospitalized patients aged >30 years Patients were randomly allocated to one of two groups: intervention with a single dose of 50,000 IU of Vit D capsules and daily 10,000 IU Vit D orally syrup from the second day of admission for 29 days n=70 and control with the intake of 1000 IU Vit D syrup orally per day for 30 days n=70 Blood samples were taken at baseline and the end of the intervention Neutrophil Lymphocyte Ratio NLR and C reactive protein CRP , erythrocyte sedimentation rate ESR , and Red Cell Distribution Width RDW were evaluated The decision tree analysis was undertaken using JMP Pro SAS version 13 Result: the average age in the intervention and control groups was 59 96±13 44 and 60 82±13 85 years, respectively There was a significant time×group effect for of CRP p=0 021 and NLR p=0 048 This finding indicates that the changes in these variables over time were significantly different between the intervention and control groups The decision tree analysis showed that age was most important factor to predict responding to patients’ vitamin D treatment Also it has also been shown that if a man is younger than 73 year old and NLR is more than 3 8, there is a 90% probability that he will respond better to vitamin D therapy Conclusion: Our results showed that a high dose of Vit D supplementation positively affected inflammatory markers in COVID 19 Further randomized control trials are needed to confirm the effects of Vit D in COVID 19 in different clinical stages of this disease
کلیدواژهها
نویسندگان
Zahra Khorasanchi
Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Student Research Committee, faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
شیوه ارجاع
Khorasanchi, Zahra,1400,Effects of high dose vitamin D supplementation on inflammatory biomarkers and prediction of factors determining the adequate amount of supplementation in confirmed cases of COVID-19; a randomized double-blinded clinical trial,2nd International Conference on Technology, Engineering, Science and Technological Business,Tehran
ارائهشده در
مجموعه مقالات چهارمین دوره کنفرانس بین المللی مطالعات میان رشته ای علوم بهداشتی، روانشناسی، مدیریت و علوم تربیتی20 اسفند 1400 · تهران