چکیده مقاله
Here Gastric cancer GC is the most common malignant tumor of the digestive system, and there are approximately one million GC patients worldwide Although the incidence of GC has declined in the past few decades, the high mortality rate of GC remains a concern While surgical resection and chemotherapy can safely and effectively prolong the survival of GC patients, ffective treatment of patients diagnosed with advanced or metastatic GC remains difficult Therefore, to improve the survival rate of GC patients, an early and accurate diagnosis is important Currently, clinical diagnosis of GC mainly involves gastroscopy, which is a costly procedure Moreover, the examinee experiences considerable discomfort during gastroscopy, limiting its potential in large scale screening The 1B cell transfer gene BTG1 is an anti proliferative gene that regulates the occurrence and development of various tumors There is no research on this gene in gastric cancer On the other hand, serum pepsinogen levels reflect the morphologic and functional status of the stomach mucosa, so they serve as a marker of chronic atrophic gastritis Although the association between BTG 1 and pepsinogen I and the clinical features and prognostic factors of various cancers has already been investigated, this potential association for GC has not yet been established Our aim was to estimate the risk of pepsinogen and BTG1 associated gastric cancer by a case control study A total of 60 patients with gastrointestinal diseases in our hospital were selected and based on the results of the study were divided into three groups: healthy n = 20 , atrophic group n = 20 , and gastric cancer group n = 20 The mean age of men and women was 48 years We collected biopsy specimens from patients with GC, atrophy, and healthy individuals using a gastroscope The RNA samples were used to perform a qRT PCR employing the designed specific primers against the BTG1 and GAPDH genes Fasting blood samples were collected and serum pepsinogen concentration was measured by immunoradiometry Conscious consent was obtained individually QRT PCR results showed that the expression of BTG1 and pepsinogen was significantly reduced in GC and atrophy samples Finally, it can be concluded that decreased BTG1 expression and decreased pepsinogen levels can act as an accurate biomarker for GC It can also indicate the function of BTG1 in the pathogenesis of GC Atrophic gastritis was also associated with an elevated risk of gastric cancer and the risk increased further with pepsinogen levels BTG1 and pepsinogen tests can be valuable for screening populations in need of further diagnosis and can help prevent unnecessary invasive endoscopic procedures
کلیدواژهها
نویسندگان
Yousef Paridar
Gastroenterology Clinic, Dezful University of Medical Sciences, Dezful, Iran
Maysam Mard-soltani
Department of Clinical Biochemistry, Faculty of Medical Sciences, Dezful University of Medical Sciences, Dezful, Iran
Saeed Khalili
Department of Biology Sciences, Shahid Rajaee Teacher Training University, Tehran, Iran
Neda Shakerian
Department of Biology Sciences, Shahid Rajaee Teacher Training University, Tehran, Iran
Somayeh Pouria Mehr
Department of Biology Sciences, Shahid Rajaee Teacher Training University, Tehran, Iran
Davood Alinezhad Dezfuli
Department of Biology Sciences, Shahid Rajaee Teacher Training University, Tehran, Iran
شیوه ارجاع
Paridar, Yousef and Mard-soltani, Maysam and Khalili, Saeed and Shakerian, Neda and Pouria Mehr, Somayeh and Alinezhad Dezfuli, Davood,1400,The role of pepsinogen and BTG1 in the diagnosis of gastric cancer,2nd International Conference on Technology, Engineering, Science and Technological Business,Tehran
ارائهشده در
مجموعه مقالات پنجمین کنفرانس بین المللی مطالعات میان رشته ای علوم بهداشتی، روانشناسی، مدیریت و علوم تربیتی26 تیر 1401