چکیده مقاله
Background: Infertility affects approximately 10 15% of couples globally, presenting significant clinical, psychological, and immunological challenges While Assisted Reproductive Technologies ART have advanced, the potential of precision nursing interventions—individualized, nurse led strategies based on patient specific needs—to optimize outcomes remains largely unquantified This systematic review and meta analysis aimed to evaluate the effectiveness of these interventions on fertility outcomes clinical pregnancy, live birth , psychological well being, and key immunological markers in patients undergoing ART Methods: A systematic literature search was conducted across PubMed, Scopus, Web of Science, and the Cochrane Library from inception to July 2025 We included randomized controlled trials RCTs and quasi experimental studies assessing nurse delivered, individualized interventions in ART patients Two independent reviewers performed study screening, data extraction, and quality appraisal using the Cochrane Risk of Bias tool A random effects model was employed for meta analysis, calculating pooled effect sizes Risk Ratios RR for dichotomous, Standardized Mean Difference SMD for continuous outcomes Heterogeneity was assessed using the I2 statistic Results: Eighteen studies encompassing 2,610 participants met the inclusion criteria Nurse led precision interventions demonstrated a significant positive impact on clinical pregnancy rates RR = 1 37, 95% CI: 1 15–1 63, p < 0 001 A substantial improvement was also observed in patient reported psychological well being SMD = 0 45, 95% CI: 0 23–0 67, p < 0 001 , primarily driven by reduced anxiety and depression scores Furthermore, the interventions favorably modulated immunological markers, evidenced by a statistically significant reduction in stress related cytokines e g , TNF alpha compared to standard care Subgroup analysis suggested that interventions integrating personalized counseling, lifestyle modification, and stress management techniques yielded the largest effects Conclusion: This study highlights the innovative and clinically important role of precision nursing in the ART setting Individualized, nurse led interventions can significantly enhance reproductive success, improve psychological health, and beneficially modulate immune responses These findings strongly support the integration of precision nursing into global ART clinical practice guidelines and establish a clear agenda for future research focusing on mechanism and long term impact
کلیدواژهها
نویسندگان
Sana Mahdian Rizi
Students Research Committee, Neyshabur University of Medical Sciences, Neyshabur, Iran
شیوه ارجاع
Mahdian Rizi, Sana,1404,Precision Nursing Interventions in Assisted Reproductive Technologies: A Systematic Review and Meta-Analysis of Fertility, Psychological, and Immunological Outcomes,17th International Conference on New Findings in Midwifery, Women, Maternity and Infertility
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