چکیده مقاله
Prostate cancer PCa is a complex disease influenced by metabolic alterations within the tumor microenvironment This study investigates the role of metabolite interconversion enzymes in PCa by analyzing differentially expressed genes DEGs using multiple gene expression datasets from the Gene Expression Omnibus GEO A total of 544 DEGs were identified, with key metabolite interconversion enzymes—including CYP3A5, PDE8B, AOX 1, BNIPL, FADS2, RRM2, ALDH3B2, and GSTM2—showing significant differential expression Functional classification of these genes revealed their involvement in critical biological processes such as oxidation reduction, hydrolase activity, and molecular transferase functions Gene co expression analysis, protein protein interaction PPI network construction, and regulatory network analysis further demonstrated the intricate interactions between these enzymes and key oncogenes and tumor suppressor genes Enrichment analysis using Gene Ontology GO and KEGG pathways highlighted their involvement in metabolic pathways that contribute to tumor progression Additionally, hub genes with high connectivity were identified, underscoring their potential as biomarkers or therapeutic targets The findings of this study provide valuable insights into the metabolic reprogramming of PCa, offering new perspectives for biomarker discovery and targeted therapeutic interventions Further experimental validation is needed to confirm the clinical relevance of these genes in prostate cancer diagnosis and treatment
نویسندگان
Abolfazl Nikpour
Department of Microbial Biotechnology, Amol University of Special Modern Technologies, Amol, Iran
Reyhane Kalantary
Department of Microbial Biotechnology, Amol University of Special Modern Technologies, Amol, Iran
Kousar Alipour
Department of Microbial Biotechnology, Amol University of Special Modern Technologies, Amol, Iran
Mojtaba Ranjbar
Department of Microbiotechnology, Faculty of Biotechnology, Amol University of Special Modern Technologies, Amol, Iran
Somayeh Rahaei
Department of Microbiotechnology, Faculty of Biotechnology, Amol University of Special Modern Technologies, Amol, Iran
شیوه ارجاع
Nikpour, Abolfazl and Kalantary, Reyhane and Alipour, Kousar and Ranjbar, Mojtaba and Rahaei, Somayeh,1403,Analysis of microarray associated with metabolite interconversion enzyme in prostate cancer,20th International Conference on Innovation and Research in Engineering Sciences
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