چکیده مقاله
Context: Some evidence highlights that there is a relationship between maternal vitamin B12 levels and the development of preeclampsia PE in pregnant women However, the relationship between PE and vitamin B12 is not clear Objective: The aim of this study was to investigate vitamin B12 levels in PE in comparison to normotensive pregnant women Data Sources: PubMed MEDLINE, Scopus and Web of Science were searched, along with the reference lists of included articles, up to August 2019 Study Selection: The literature was searched for observational studies that investigated vitamin B12 levels in PE Data Extraction: Data were extracted independently by two researchers Data were pooled using a random effects model Results: Our findings showed that B12 vitamin levels were significantly lower in women with PE versus healthy women 15 24 pg/ml 95% CI: 27 52, 2 954; P < 0 015 However, there was a high heterogeneity between the assessed studies I2 = 97 8%, P =0 0103 The subgroup analysis, based on folic acid supplementation, homocysteine concentrations and gestational age at the time of vitamin B12 sampling, did not find the sources of heterogeneity Conclusions: We found that women with PE had significantly lower vitamin B12 concentrations versus normotensive pregnant women
کلیدواژهها
نویسندگان
Farzaneh Mardali
Student Research Committee, Iran University of Medical Sciences, Tehran, Iran
Somaye Fatahi
Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran
Hamed Kord Varkaneh
Student Research Committee, Department Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran Department of Clini
Mohammad Hassan Sohouli
Student Research Committee, Iran University of Medical Sciences, Tehran, Iran Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran
Farzad Shidfar
Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran
Mihnea-Alexandru Găman
Carol Davila University of Medicine and Pharmacy, ۸ Eroii Sanitari Boulevard, Bucharest ۰۵۰۴۷۴, Romania Center of Hematology and Bone Marrow Transplantation, Fundeni Clinical Institute, ۲۵۸ Fundeni Road, Bucharest ۰۲۲۳۲۸, Romania
شیوه ارجاع
Mardali, Farzaneh and Fatahi, Somaye and Kord Varkaneh, Hamed and Sohouli, Mohammad Hassan and Shidfar, Farzad and Găman, Mihnea-Alexandru,1399,Abnormal Maternal Levels of Serum B12 Are Associated with Preeclampsia: A Systematic Review and Meta-Analysis Level of serum B12 is associated with preeclampsia,3rd International Conference on New Findings in Midwifery, Obstetrics, Gynecology and Infertility
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