چکیده مقاله
The role of epididymis in post testicular maturation of spermatozoa is to gain the potential to fertilize the ovum It is well known that thyroid malfunction has a negative impact on male reproductive system Hypothyroidism causes marked structural and functional changes in the ductus epididymis, as well as is able to influence extra cellular matrix ECM proteins secretion and cell death This study was designed to characterize some changes induced by hypothyroidism in the mouse epididymis 20 Balb/C mice were randomly divided into control group, and hypothyroid group that was received 0 05% 6 n propyl 2 thiouracil PTU After the confirmation of hypothyroidism, Real Time PCR, immunohistochemistry and Periodic Acid Schiff PAS staining, TUNEL assay and biochemical measurements were carried out laminin α5 and collagen IV mRNA levels were upregulated in the hypothyroid group compared to the control group p
کلیدواژهها
نویسندگان
Fatemeh Alipour
Department of Anatomy and Cellular Biology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Department of Anatomy and Cellular Biology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Mehdi Jalali
Department of Anatomy and Cellular Biology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Department of Anatomy and Cellular Biology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Mohammad Reza Nikravesh
Department of Anatomy and Cellular Biology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Department of Anatomy and Cellular Biology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Alireza Fazel
Department of Anatomy and Cellular Biology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Department of Anatomy and Cellular Biology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Mojtaba Sankian
Bou Ali Research Institute, Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Elnaz Khordad
Department of Physiology, School of Paramedical Sciences, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran Neuroscience Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran
شیوه ارجاع
Alipour, Fatemeh and Jalali, Mehdi and Nikravesh, Mohammad Reza and Fazel, Alireza and Sankian, Mojtaba and Khordad, Elnaz,1399,Extracellular matrix interaction and apoptosis of the epididymal epithelium following hypothyroidism in Balb/C mouse,3rd International Conference on New Findings in Midwifery, Obstetrics, Gynecology and Infertility
ارائهشده در
مجموعه مقالات سومین کنفرانس بین المللی یافته های نو در مامایی، زنان، زایمان و نازایی2 اسفند 1399