چکیده مقاله
Introduction:Thiosemicabazone and theirmetl complexes are active biological compounds that have antibactrial , antifungal and antitumor properties for this perpose, in this article ,the labeling of acetyl acetate bis thiosemicarbazone complex by Scandium 46 isotope has been done Methods: Scandium 46 was produced in the Tehran reaserch reactor by bombarding Sc 45 by thermal neutron flux of 3 5 1013 n cm s 1 during the 45 Sc n,γ 46 Sc reaction then AATS complex was synthesized through chemical processes and after labeling the complex by Scandium 46, the radiochemical purity was investigated by thin layer chromatography TLC and radiochromatography ITLC ,and finally its biodistribution was investigated after the injection of the labeled complex into mice Results:the preparation of radionuclide with radiochemical purity above >90% has happened and radiochemical purity of the acetyl acetate bis thiosemicarbazone complex AATS labeled by Sc 46 has been very favorable >98% and the study of the biodistribution of AATS 46Sc complex was conducted within 48 hours and noticeableDDiscuss:as seen, AATS has been successfully labeled by 46 Sc isotope and its absrption mechanism has been very good, and it indicates that by labeling the above compound with Scandium 47
کلیدواژهها
نویسندگان
Hamideh Bakhshi
Leila Moghaddam BanaemSoudeh Sadat Saladi
Leila Moghaddam Banaem
Hamideh BakhshiSoudeh Sadat Saladi
Soudeh Sadat Saladi
Hamideh BakhshiLeila Moghaddam Banaem
شیوه ارجاع
Bakhshi, Hamideh and Moghaddam Banaem, Leila and Saladi, Soudeh Sadat,1401,Preliminary Dosimetry Study of 46Sc-AATS for Human Based on Biodistribution Data in wild-type mice,Fourth National Conference on Interdisciplinary Research in Engineering and Management,Tehran
ارائهشده در
مجموعه مقالات چهارمین همایش ملی تحقیقات میان رشته ای در علوم مهندسی و مدیریت26 تیر 1401 · تهران