چکیده مقاله
The advent of the new malady COVID 19 has challenged the search for effective treatments Because the most severe clinical side effects related with COVID 19 malady appear to be extreme intense respiratory disorder, azithromycin has been recommended as a pharmacotherapy potential in this area There are different speculations around the conceivable mechanism of activity of azithromycin versus SARS CoV 2 In different research, we studied the various antiviral mechanism of azithromycin In the first step, it must be stated that the proper growth and function of the endosome requires an acidic environment These environmental conditions also apply to the effective growth and penetration of viruses such as influenza, AIDS, and even SARS CoV 2 to host cells Interleukin 2 that gets included in the innate immune reactions of bacterial or viral pathogens by proliferating and differentiating T lymphocytes Interleukin 2 production must be maintained to trigger an innate immune reaction in patients with COVID 19 and produce sufficient memory T and natural killer cells and persuade T regulatory cells to suppress inflammation Azithromycin can permit an adequate memory T cell amount to be kept up and a greater immunization We have updated the evidence and selected all relevant items to understand the mechanism of azithromycin, clinical efficacy, and their side effects in the treatment of COVID 19 patients The most common side effect and drug interaction in patients with COVID 19 for whom azithromycin in prescribed, included pruritus, headache and nausea Concomitant use of chloroquine and hydroxychloroquine with azithromycin can also lead to life threatening arrhythmias
کلیدواژهها
نویسندگان
Ramin Ataee
Pharmaceutical Sciences Research Center,Mazandaran University of Medical Sciences,Sari Iran
Parisa Saberi-Hasanabadib
Department of Toxicology and Pharmacology, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
شیوه ارجاع
Ataee, Ramin and Saberi-Hasanabadib, Parisa,1400,Azithromycin as a treatment of COVID-19: Pharmacological mechanism, clinical efficacy, and prescribing guidelines,Seventh International Conference on Health, Treatment and Health Promotion
ارائهشده در
مجموعه مقالات هفتمین کنفرانس بین المللی بهداشت،درمان و ارتقای سلامت30 مهر 1400