چکیده مقاله
Introduction: Menopausal status and estrogen levels can reportedly influence COVID 19 infection and its outcomes via different mechanisms We aimed to investigate the possible association between menopausal status and incidence and outcomes in COVID 19 patients Materials and methods: Combinations of keywords COVID 19 , menopause , and estrogen were used to search PubMed, Embase, Web of Science, and Scopus databases for articles reporting the incidence and outcomes of COVID 19 discharge, length of admission, intensive care, or mortality in pre menopausal and premenopausal women, available through December 29, 2022 Data from studies comparing the incidence of COVID 19 infection with the age matched male population were pooled and meta analyzed using a random effects model Results: Overall, 1564 studies were retrieved, of which 12 were finally included in the systematic review to compare disease outcomes, and six were meta analyzed for the incidence of COVID 19 in premenopausal and postmenopausal women All studies reported better COVID 19 associated outcomes in premenopausal women compared with postmenopausal women After adjusting for confounding factors, three studies found better outcomes in postmenopausal women, and two found no association between menopausal status and COVID 19 outcomes Our meta analysis found higher incidence of COVID 19 infection among pre menopausal women than post menopausal women, when compared with age matched men odds ratio=1 270; 95% confidence interval 1 086, 1 486 ; P=0 003 Conclusions: The incidence of COVID 19 was significantly higher in premenopausal women than in postmenopausal women when compared with age matched men Although premenopausal women may have more favorable COVID 19 associated outcomes, the presumed preventive effect of estrogens on the incidence and related outcomes of COVID 19 in premenopausal women cannot be proven at present Further longitudinal studies comparing pre and post menopausal women are required to provide further insight into this matter
کلیدواژهها
نویسندگان
Ezat Hajmolarezaei
Assistant Professor, Department of Obstetrics and Gynecology, Faculty of Medicine, MashhadUniversity of Medical Sciences, Mashhad, Iran
شیوه ارجاع
Hajmolarezaei, Ezat,1402,Incidence and outcomes associated with menopausal status in COVID-19 patients: A systematic review and meta-analysis,The 13th International Conference on Health, Treatment and Health Promotion
ارائهشده در
مجموعه مقالات سیزدهمین کنفرانس بین المللی بهداشت، درمان و ارتقای سلامت12 خرداد 1402