چکیده مقاله
Simultaneous delivery of chemotherapy drugs increases the sensitivity of cancer cells to these drugs Polymeric nanoparticles are considered a suitable platform for the transfer of anticancer agents For this purpose, we prepared PCL PEG PCL nanoparticles containing paclitaxel and curcumin using double emulsion method and then coated it with chitosan acidfolic conjugate for proper delivery of drugs to cancer cells The inhibitory effect of prepared nanoparticles on cell growth was evaluated using MTT method in human breast cancer cell line MDA MB 231 The developed nanoparticles had a spherical structure and a smooth surface Nanoparticles containing paclitaxel and curcumin had a size of about 130 nm and a surface charge of about 5 mV, which increased after coating with chitosan folic acid conjugate Nanoparticle encapsulation efficiency for paclitaxel and curcumin was about 98% and 79%, respectively The results of cytotoxicity in laboratory conditions showed that nanoparticles containing both paclitaxel and curcumin have significant growth inhibitory effects compared to the free combined form of this drug as well as the single form of these drugs These findings show that targeted PCL PEG PCL nanoparticles with folic acid with simultaneous delivery of paclitaxel and curcumin can increase the therapeutic and functional effects of these two drugs in breast cancer
کلیدواژهها
نویسندگان
Sajad Jamali
Department of Clinical Biochemistry, Shahrood Branch, Islamic Azad University, Shahrood, Iran
Behzad Jamali
Department of Clinical Biochemistry, Shahrood Branch, Islamic Azad University, Shahrood, Iran
Soodabeh Davaran
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
شیوه ارجاع
Jamali, Sajad and Jamali, Behzad and Davaran, Soodabeh,1402,Combination treatment of breast cancer with targeted polymeric nanoparticles containing paclitaxel and curcumin,The fourteenth international conference on health, treatment and health promotion
ارائهشده در
مجموعه مقالات چهاردهمین کنفرانس بین المللی بهداشت، درمان و ارتقای سلامت27 مرداد 1402