چکیده مقاله
Exposure to cell phone electromagnetic fields (CP-EMFs), is connected with cell death, infertility and other pathologic effects and ultimate diseases, including cancer. The ion translocation through voltage-gated potassium channels of cell and mitochondrial membranes is affected by CP-EMF that leads to adverse effect on the bioelectric profile of cell and its physiological status, subsequently. As a result, the abnormal and damaging electrical pulses and bursts induced by CP-EMFs, activates undesired physiological events including; overproduction of reactive oxygen species and free radicals that leads to DNA damage and over or mis-expression of cancer associated genes. Here, the mitBk channels extracted from rat brains mitochondria, reconstituted into egg yolk lipid bilayers, and different aspects of single channel activity including; conductance, gating properties, and voltage sensitivity were recorded in the absence and presence of CP-EMFs using EPC-9 Heka Instrument. The recorded data were analyzed by Clampfit software of Axon package. The results showed CP-EMFs increased channel open probability and number of translocating ions. The extreme driving forces exerted by CP-EMFs on ions in the vicinity of the channel caused a huge number of ions translocation at high frequency. The huge non-physiological ion translocation imposed by CP-MF disrupts bioelectric of cells may cause cancer.
کلیدواژهها
نویسندگان
M Rezaei
Institute of Biochemistry and Biophysics (IBB), University of Tehran, Tehran, Iran.
H Mobasheri
Institute of Biochemistry and Biophysics (IBB), University of Tehran, Tehran, Iran.
A Eliassi
Neuroscience Research Center and Department of Physiology, Shahid Beheshti University of Medical Sciences, Evin, Tehran, Iran.
J Fahanik-Babaei
Electrophysiology Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
شیوه ارجاع
Rezaei, M and Mobasheri, H and Eliassi, A and Fahanik-Babaei, J,1403,Cell phone EMF effect on mitBK channel activity, a possible biophysical cause of cancer,1st International Congress on Cancer Prevention,Zanjan
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