چکیده مقاله
Gastric cancer is one of the most common causes of cancer-related death worldwide, and the molecular mechanisms involved in gastric carcinogenesis are still not fully understood. Insufficient knowledge about the molecular elements involved in the disease has hindered development of diagnostic/prognostic biomarkers. Thus, patients are diagnosed at higher stages, which leads to a poor prognosis for these patients. This study aimed to determine highly expressed genes in 111 human gastric cancer tissues compared to 21 non-cancerous gastric tissues by high-density oligonucleotide microarray. The data of the study of Query DataSets-GSE54129 from NCBI Under the platform Affymetrix Human Genome U133 Plus 2.0 Array were extracted and analyzed. In this study, 1036 genes were highly over-expressed (logFC>0) in cancerous tissue was compared to tissue from healthy people. Conclusion: The highly over-expressed gene patterns and some important genes were identified, which might be useful in further study on carcinogenesis, progression, and metastasis of GC.
کلیدواژهها
نویسندگان
Maryam Moradi
Researcher, PhD in Statistics, Department of Biostatistics and Epidemiology, School of Public Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran,
Sarah L Kerns
Associate Professor, Department of Radiation Oncology, The Medical College of Wisconsin, Milwaukee, WI, USA,
شیوه ارجاع
Moradi, Maryam and L Kerns, Sarah,1403,Discovery of Genes Differentially EXpressed in Gastric Cancer,1st International Congress on Cancer Prevention,Zanjan
ارائهشده در
مجموعه مقالات اولین کنگره بین المللی پیشگیری از سرطان28 شهریور 1403 · زنجان