چکیده مقاله
Clinical research on herbal based dentifrice /− mouth rinse products is very limited compared with the plethora of research on conventional oral care products under normal oral hygiene conditions The aim of this study was to determine the anti inflammatory effects of a novel plant Carica papaya leaf extract CPLE on interdental bleeding in healthy subjects In this randomized, single blind parallel design study, the eligible subjects were generally healthy non smokers, aged 18–26, who exhibited healthy periodontal conditions upon study entry The participants were equally randomized into the following four groups: CPLE dentifrice, CPLE dentifrice and mouthwash, sodium lauryl sulfate SLS free enzyme containing dentifrice and SLS free enzyme containing dentifrice with essential oil EO mouthwash Subjects were instructed to brush their teeth twice a day without changing their other brushing habits Interdental bleeding BOIP was measured from inclusion T0 until the fourth week T4 of the study Clinical efficacy was assessed after one, two, three and four weeks of home use The analyses compared BOIP between groups and were then restricted to participants with ≥70% and then ≥80% bleeding sites at T0 Pairwise comparisons between groups were performed at T0 and T4, and a logistic regression identified correlates of gingival bleeding T4 Among 100 subjects 2273 interdental sites , the median percentage of bleeding sites per participant at T0 was 65% The bleeding sites dramatically decreased in all groupsbetween T0 and T4 relative variations from −54% to −75%, p < 0 01 for all Gingival bleeding did not significantly differ between the CPLE dentifrice and the SLS free dentifrice /− EO mouthwash groups from p = 0 05 to p = 0 86 , regardless of the baseline risk level Among the CPLE dentifrice users, fewer bleeding sites were observed when toothpaste and mouthwash were combined compared to bleeding sites in those who used toothpaste alone 21% vs 32%, p = 0 04 CPLE dentifrice/mouthwash provides an efficacious and natural alternative to SLS free dentifrice /−EO containing mouthwash when used as an adjunct to mechanical oral care to reduce interdental gingival inflammation
کلیدواژهها
نویسندگان
AmirMohammad Baghi
Department of Dentistry at Near East University, Nicosia, North Cyprus
Samin Nikakhtar
Department of Pharmacy at Eastern Mediterranean University
شیوه ارجاع
Baghi, AmirMohammad and Nikakhtar, Samin,1399,The effect of toothpaste / mouthwash containing Carica papaya leaf leaf extract on interdental gingival bleeding,International Congress on Food Science & Technology & Agriculture and Food Security,Karaj
ارائهشده در
مجموعه مقالات کنگره بین المللی علوم و صنایع غذایی، کشاورزی و امنیت غذایی30 شهریور 1399 · کرج