چکیده مقاله
Introduction: Rabies remains a significant global challenge to public health, where immunization serves as the primary preventive strategy Currently licensed inactivated rabies vaccines frequently necessitate repeated administration and are limited by the absence of strong adjuvants to boost their effectiveness The objective of this research was to examine the linkage of fully inactivated rabies virus with mannan through an oxidative process as a method to augment immunological reactions relative to a conventional rabies vaccine Specifically, the study focused on conjugating the inactivated virus with oxidized mannan referred to as Rab OxMan Materials and Methods: Mice received intraperitoneal immunizations of 350 µg of the Rab OxMan preparation on days 1 and 7 Serum was obtained two weeks post vaccination to quantify IgG, IgM, and TNF α concentrations via ELISA Vaccine strength was further assessed using the standard NIH test protocol Results: The results indicated a statistically significant elevation in IgG and a reduction in IgM titers in the Rab OxMan cohort relative to the group receiving the alum adjuvanted vaccine p
کلیدواژهها
نویسندگان
Anahita Bahmanjeh
Department of Virology Vaccines, Production and Research Unit, Pasteur Institute of Iran, Karaj, Iran
Zahra Jalali
Department of Quality Control, Pasteur Institute of Iran
Farzaneh Malekpour
Department of Medical Microbiology, Faculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran
Mohsen Enayatsefat
Department of Microbiology, Faculty of Science, Islamic Azad University, Science and Research Branch, Tehran, Iran
Parivash Ghaderinia
Department of Microbiology, Zanjan Branch, Islamic Azad University, Zanjan, Iran
Seyyed Danial Mirmiran
State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University Wuhan, China
رزومه علمی کاربران
درباره سیویلیکاتبلیغات در سیویلیکاآمار علمی ایرانتقویم علمی ایرانداده کاوی مقالاتطرح های پژوهشی
شیوه ارجاع
در صورتی که می خواهید در اثر پژوهشی خود به این مقاله ارجاع دهید، به سادگی می توانید از عبارت زیر در بخش منابع و مراجع استفاده نمایید: Bahmanjeh, Anahita and Jalali, Zahra and Malekpour, Farzaneh and Enayatsefat, Mohsen and Ghaderinia, Parivash and Mirmiran, Seyyed Danial,1404,Novel Immunostimulant for Potentiating Vaccine Efficacy in Animal Rabies Immunization,2nd International Congress on Sustainable Urban Engineering and Development,https://civilica.com/doc/2624500
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