چکیده مقاله
A new, simple, rapid, accurate, sensitive and cost effective spectrophotometric stability indicating assay method was developed for the quantification of Tinidazole in bulk and validated according to ICH guidelines using different parameters In the present study an attempted has been made to develop an effective method which will surpass the disadvantages associate with other reported methods like tedious in use, less sensitive and costly etc The assay method was based on the forced degradation study of Tinidazole under different ICH recommended stress conditions like hydrolytic, oxidation, thermal, and photolysis Drug shown maximum absorption at 322nm and a regression coefficient value R2 of 0 999 indicates linearity followed within the concentration range of 5µg/ml to 50µg/ml During forced degradation study, Tinidazole was significantly degraded in alkaline conditions whereas mild degradation occurs in acidic, neutral and oxidative stress The drug was stable to dry heat and photolytic degradation conditions Statistical validation result of the developed method indicates that it was a simple, precise, reproducible, selective, specific and accurate method for analysis of Tinidazole and could be successfully adopted to estimate the drug in bulk and formulations
کلیدواژهها
نویسندگان
Mostafa Khajeh Dehaghani
Student of pharmaceutical supervision at Tehran University of Medical Sciences
رزومه علمی کاربران
درباره سیویلیکاتبلیغات در سیویلیکاآمار علمی ایرانتقویم علمی ایرانداده کاوی مقالاتطرح های پژوهشی
شیوه ارجاع
در صورتی که می خواهید در اثر پژوهشی خود به این مقاله ارجاع دهید، به سادگی می توانید از عبارت زیر در بخش منابع و مراجع استفاده نمایید: Khajeh Dehaghani, Mostafa,1404,Stability-indicating assay method for determination of Tinidazole in active substance with Spectroscopic approach,Fourth International Conference for Iranian Hygienics and Health Sciences Students,Tehran,https://civilica.com/doc/2636156
ارائهشده در
مجموعه مقالات دومین کنفرانس بین المللی عمران، معماری، توسعه و بازآفرینی زیرساخت های شهری30 بهمن 1404