چکیده مقاله
Hydrogel nanoparticles HNPs represent a rapidly advancing class of drug delivery systems with strong potential in cancer therapy Their highly hydrated polymeric structure enables efficient encapsulation of diverse therapeutic agents while ensuring biocompatibility and tunable mechanical properties By responding to physiological and tumor specific stimuli such as pH, temperature, and enzymatic activity, HNPs can deliver drugs in a controlled and localized manner, reducing systemic toxicity and enhancing treatment outcomes Additionally, passive targeting through enhanced permeability and retention, together with surface modification using ligands for active targeting, supports improved selectivity toward tumor tissues and contributes to overcoming multidrug resistance Despite these advantages, challenges including scalable synthesis, long term stability, and variability in drug release kinetics still limit clinical translation Continued development in material engineering and integration with advanced therapeutic strategies is expected to accelerate the application of HNPs as a promising platform in next generation precision oncology
کلیدواژهها
نویسندگان
Seyedhamidreza Emadiyanrazavi
۱ Department of Biomedical Engineering, Central Tehran Branch, Islamic Azad University, Tehran, Iran
شیوه ارجاع
Emadiyanrazavi, Seyedhamidreza,1404,Hydrogel Nanoparticles as Advanced Platforms for Targeted and Controlled Cancer Drug Delivery,27th National Conference on Electrical, Computer and Mechanical Engineering,Shirvan
ارائهشده در
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