چکیده مقاله
Background: Clopidogrel is a potent platelet activation and aggregation inhibitor that prevents thrombosis in coronary artery diseases In comparison to locally produced generic one Osvix® , original brand of clopidogrel Plavix is expensive Objectives: This study was designed to evaluate the effectiveness and uniformity of Osvix® versus Plavix® in patients with previous percutaneous angioplasty PCI by means of platelet aggregation indexes Patients and Methods: This randomized, double blind clinical study was conducted at Shahid Madani Heart Hospital, Tabriz, Iran, and 129 patients with previous PCI were enrolled in two independent treatment groups All patients participated in this study were on dual antiplatelet therapy at least for 30 days ASA 80 mg/day and clopidogrel 75 mg/day and a stat dose of 300 mg of Clopidogrel before PCI were administered for all patients To evaluate the anti platelet activity, blood samples were taken from the patients and platelet aggregation test was performed Results: The total study population represents a group of 129 patients 99 men and 30 women with mean age of 57 7 ± 9 7 years with stable angina pectoris The baseline characteristics and laboratory findings of two groups except MPV were not different statistically The mean platelets aggregation at 30th day was 13 7±7 0 in Plavix® group and 14 8±5 8 in Osvix® group P value=0 35 Conclusions: This study showed the Iranian brand of Clopidogrel Osvix® was not significantly different from the original brand Plavix in terms of performance factors in preventing platelet aggregation in patients
کلیدواژهها
نویسندگان
Reza Hajizadeh
Assistant Professor of Cardiology, Urmia University of Medical Sciences, Urmia, Iran
شیوه ارجاع
Hajizadeh, Reza,1402,In vitro platelet inhibition of generic clopidogrel,16th International Conference on Health, Treatment and Health Promotion
ارائهشده در
مجموعه مقالات شانزدهمین کنفرانس بین المللی بهداشت، درمان و ارتقای سلامت27 بهمن 1402