چکیده مقاله
Introduction: Genetic disorders are a major cause of male infertility, with conditions like Klinefelter’s syndrome KS and Y chromosome microdeletions responsible for 10 15% of azoospermia and severe oligozoospermia cases Advances in genetic technologies have improved our understanding of infertility, enabling better diagnosis, prognosis, and treatment Routine screening for Y chromosome abnormalities, particularly AZF microdeletions, provides essential genetic information for Assisted Reproductive Technology ART Objectives: This study evaluates the effectiveness of screening for Y chromosome impairments in infertile males Early detection allows for appropriate treatment strategies, increasing the chances of fertility restoration Methods: A literature review was conducted using PubMed, covering studies from 1998 to the present Results: Infertility affects both men and women equally Y chromosome microdeletions are a leading cause of male infertility, with Yq deletions often leading to spermatogenic failure In a study of 3,073 sterile men, 5 5% had oligozoospermia, while 8 3% had non obstructive azoospermia AZFa and AZFb deletions result in poor sperm retrieval outcomes, while AZFc deletions offer better chances for sperm retrieval and ART success AZFc deletions occur in 7 10% of oligozoospermic and 15 20% of azoospermic men The European Academy of Andrology recommends Y chromosome screening for infertile men with sperm counts below 5 million Discussion: Genetic screening is crucial for diagnosing male infertility, guiding ART decisions, and informing genetic counseling Early detection helps optimize treatment and prevents the transmission of deletions to offspring Routine screening improves clinical outcomes and enhances reproductive planning
کلیدواژهها
نویسندگان
Ali Khanbazi
Genetics laboratory, Tehran, Iran
شیوه ارجاع
Khanbazi, Ali,1404,The Role of Y-Chromosome Microdeletion Screening in Male Infertility,19th International Conference on Health, Treatment and Health Promotion
ارائهشده در
مجموعه مقالات نوزدهمین کنفرانس بین المللی بهداشت، درمان و ارتقای سلامت20 فروردین 1404